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Thiabendazole/bentonites hybrids as controlled release systems
[Display omitted] •Thiabendazole intercalates in the interlamellar space of bentonite.•The nature of the interlamellar cation influenced the adsorption capacity of bentonite.•Release tests showed that part of the drugs are still adsorbed on the bentonites.•The solids have shown to be promising for p...
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Published in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2019-04, Vol.176, p.249-255 |
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creator | Cavalcanti, Graycyelle R.S. Fonseca, Maria G. da Silva Filho, Edson C. Jaber, Maguy |
description | [Display omitted]
•Thiabendazole intercalates in the interlamellar space of bentonite.•The nature of the interlamellar cation influenced the adsorption capacity of bentonite.•Release tests showed that part of the drugs are still adsorbed on the bentonites.•The solids have shown to be promising for pharmaceutical applications.
Clay minerals are commonly used in pharmaceutical products as excipients and active agents. New drug vehicles based on clay minerals have been developed. In this work, sodium (BentNa), calcium (BentCa) and magnesium (BentMg) exchanged bentonites were used for the sorption of thiabendazole (TBZ), and their potential use as controlled release systems was evaluated. Pristine bentonite and exchanged bentonites were characterized by X-ray diffraction, infrared spectroscopy, thermogravimetry and transmission electron microscopy (TEM), and the influence of the different parameters such as pH, contact time and initial concentration of the drug was investigated. The maximum adsorption reached after 45 min period with 2000 mg L−1 of thiabendazole to BentNa and after 105 min with 1300 mg L−1 to BentCa and BentMg, respectively. The maximum adsorbed quantities of thiabendazole were 164.4; 152.3 and 133.3 mg g−1 for BentNa, BentCa and BentMg, respectively. The emission profiles obtained for the bentonite/drug hybrids were similar when simulated body fluids were used and these emission profiles were fitted according to the Korsmeyer-Peppas kinetic model. |
doi_str_mv | 10.1016/j.colsurfb.2018.12.030 |
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•Thiabendazole intercalates in the interlamellar space of bentonite.•The nature of the interlamellar cation influenced the adsorption capacity of bentonite.•Release tests showed that part of the drugs are still adsorbed on the bentonites.•The solids have shown to be promising for pharmaceutical applications.
Clay minerals are commonly used in pharmaceutical products as excipients and active agents. New drug vehicles based on clay minerals have been developed. In this work, sodium (BentNa), calcium (BentCa) and magnesium (BentMg) exchanged bentonites were used for the sorption of thiabendazole (TBZ), and their potential use as controlled release systems was evaluated. Pristine bentonite and exchanged bentonites were characterized by X-ray diffraction, infrared spectroscopy, thermogravimetry and transmission electron microscopy (TEM), and the influence of the different parameters such as pH, contact time and initial concentration of the drug was investigated. The maximum adsorption reached after 45 min period with 2000 mg L−1 of thiabendazole to BentNa and after 105 min with 1300 mg L−1 to BentCa and BentMg, respectively. The maximum adsorbed quantities of thiabendazole were 164.4; 152.3 and 133.3 mg g−1 for BentNa, BentCa and BentMg, respectively. The emission profiles obtained for the bentonite/drug hybrids were similar when simulated body fluids were used and these emission profiles were fitted according to the Korsmeyer-Peppas kinetic model.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2018.12.030</identifier><identifier>PMID: 30623812</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adsorption ; Bentonite - chemistry ; Chemical Sciences ; Clay minerals ; Clay/drugs hybrids ; Delayed-Action Preparations - pharmacology ; Drug delivery system ; Drug Liberation ; Hydrogen-Ion Concentration ; Kinetics ; Models, Theoretical ; Spectroscopy, Fourier Transform Infrared ; Thiabendazole ; Thiabendazole - chemistry ; Time Factors ; X-Ray Diffraction</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2019-04, Vol.176, p.249-255</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-a73ffbc2399d8655b3d2143737b11afc2c9e6c80ed287b6b623ffc61e5c90d843</citedby><cites>FETCH-LOGICAL-c487t-a73ffbc2399d8655b3d2143737b11afc2c9e6c80ed287b6b623ffc61e5c90d843</cites><orcidid>0000-0003-0988-2970 ; 0000-0001-7772-1023</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30623812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-02169301$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Cavalcanti, Graycyelle R.S.</creatorcontrib><creatorcontrib>Fonseca, Maria G.</creatorcontrib><creatorcontrib>da Silva Filho, Edson C.</creatorcontrib><creatorcontrib>Jaber, Maguy</creatorcontrib><title>Thiabendazole/bentonites hybrids as controlled release systems</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>[Display omitted]
•Thiabendazole intercalates in the interlamellar space of bentonite.•The nature of the interlamellar cation influenced the adsorption capacity of bentonite.•Release tests showed that part of the drugs are still adsorbed on the bentonites.•The solids have shown to be promising for pharmaceutical applications.
Clay minerals are commonly used in pharmaceutical products as excipients and active agents. New drug vehicles based on clay minerals have been developed. In this work, sodium (BentNa), calcium (BentCa) and magnesium (BentMg) exchanged bentonites were used for the sorption of thiabendazole (TBZ), and their potential use as controlled release systems was evaluated. Pristine bentonite and exchanged bentonites were characterized by X-ray diffraction, infrared spectroscopy, thermogravimetry and transmission electron microscopy (TEM), and the influence of the different parameters such as pH, contact time and initial concentration of the drug was investigated. The maximum adsorption reached after 45 min period with 2000 mg L−1 of thiabendazole to BentNa and after 105 min with 1300 mg L−1 to BentCa and BentMg, respectively. The maximum adsorbed quantities of thiabendazole were 164.4; 152.3 and 133.3 mg g−1 for BentNa, BentCa and BentMg, respectively. The emission profiles obtained for the bentonite/drug hybrids were similar when simulated body fluids were used and these emission profiles were fitted according to the Korsmeyer-Peppas kinetic model.</description><subject>Adsorption</subject><subject>Bentonite - chemistry</subject><subject>Chemical Sciences</subject><subject>Clay minerals</subject><subject>Clay/drugs hybrids</subject><subject>Delayed-Action Preparations - pharmacology</subject><subject>Drug delivery system</subject><subject>Drug Liberation</subject><subject>Hydrogen-Ion Concentration</subject><subject>Kinetics</subject><subject>Models, Theoretical</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Thiabendazole</subject><subject>Thiabendazole - chemistry</subject><subject>Time Factors</subject><subject>X-Ray Diffraction</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LJDEQhoMoOrr7F6SPeug2lXQn3ZdFkd1VGPCi55CPaiZDpuMmPcL46zfDqFdPVRTPW1U8hFwCbYCCuFk3Noa8TaNpGIW-AdZQTo_IAnrJ65YLeUwWdGCyllJ0Z-Q85zWllLUgT8kZp4LxHtiC_HpeeW1wcvo9Brwp3RwnP2OuVjuTvMuVzpWN05xiCOiqhAF1xirv8oyb_IOcjDpk_PlRL8jLn9_P9w_18unv4_3dsrZtL-daSz6OxjI-DK4XXWe4Y9ByyaUB0KNldkBhe4qO9dIIU74bRysAOztQ17f8glwf9q50UK_Jb3Taqai9erhbqv2MMhADp_AGhb06sK8p_ttintXGZ4sh6AnjNqtCdqIbKO8KKg6oTTHnhOPXbqBq71mt1adntfesgKniuQQvP25szQbdV-xTbAFuDwAWK28ek8rW42TR-YR2Vi767278BxUFkdQ</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Cavalcanti, Graycyelle R.S.</creator><creator>Fonseca, Maria G.</creator><creator>da Silva Filho, Edson C.</creator><creator>Jaber, Maguy</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0003-0988-2970</orcidid><orcidid>https://orcid.org/0000-0001-7772-1023</orcidid></search><sort><creationdate>20190401</creationdate><title>Thiabendazole/bentonites hybrids as controlled release systems</title><author>Cavalcanti, Graycyelle R.S. ; Fonseca, Maria G. ; da Silva Filho, Edson C. ; Jaber, Maguy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-a73ffbc2399d8655b3d2143737b11afc2c9e6c80ed287b6b623ffc61e5c90d843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adsorption</topic><topic>Bentonite - chemistry</topic><topic>Chemical Sciences</topic><topic>Clay minerals</topic><topic>Clay/drugs hybrids</topic><topic>Delayed-Action Preparations - pharmacology</topic><topic>Drug delivery system</topic><topic>Drug Liberation</topic><topic>Hydrogen-Ion Concentration</topic><topic>Kinetics</topic><topic>Models, Theoretical</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Thiabendazole</topic><topic>Thiabendazole - chemistry</topic><topic>Time Factors</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cavalcanti, Graycyelle R.S.</creatorcontrib><creatorcontrib>Fonseca, Maria G.</creatorcontrib><creatorcontrib>da Silva Filho, Edson C.</creatorcontrib><creatorcontrib>Jaber, Maguy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cavalcanti, Graycyelle R.S.</au><au>Fonseca, Maria G.</au><au>da Silva Filho, Edson C.</au><au>Jaber, Maguy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thiabendazole/bentonites hybrids as controlled release systems</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>176</volume><spage>249</spage><epage>255</epage><pages>249-255</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>[Display omitted]
•Thiabendazole intercalates in the interlamellar space of bentonite.•The nature of the interlamellar cation influenced the adsorption capacity of bentonite.•Release tests showed that part of the drugs are still adsorbed on the bentonites.•The solids have shown to be promising for pharmaceutical applications.
Clay minerals are commonly used in pharmaceutical products as excipients and active agents. New drug vehicles based on clay minerals have been developed. In this work, sodium (BentNa), calcium (BentCa) and magnesium (BentMg) exchanged bentonites were used for the sorption of thiabendazole (TBZ), and their potential use as controlled release systems was evaluated. Pristine bentonite and exchanged bentonites were characterized by X-ray diffraction, infrared spectroscopy, thermogravimetry and transmission electron microscopy (TEM), and the influence of the different parameters such as pH, contact time and initial concentration of the drug was investigated. The maximum adsorption reached after 45 min period with 2000 mg L−1 of thiabendazole to BentNa and after 105 min with 1300 mg L−1 to BentCa and BentMg, respectively. The maximum adsorbed quantities of thiabendazole were 164.4; 152.3 and 133.3 mg g−1 for BentNa, BentCa and BentMg, respectively. The emission profiles obtained for the bentonite/drug hybrids were similar when simulated body fluids were used and these emission profiles were fitted according to the Korsmeyer-Peppas kinetic model.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30623812</pmid><doi>10.1016/j.colsurfb.2018.12.030</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0988-2970</orcidid><orcidid>https://orcid.org/0000-0001-7772-1023</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adsorption Bentonite - chemistry Chemical Sciences Clay minerals Clay/drugs hybrids Delayed-Action Preparations - pharmacology Drug delivery system Drug Liberation Hydrogen-Ion Concentration Kinetics Models, Theoretical Spectroscopy, Fourier Transform Infrared Thiabendazole Thiabendazole - chemistry Time Factors X-Ray Diffraction |
title | Thiabendazole/bentonites hybrids as controlled release systems |
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