Antioxidant Properties of Adrenaline in the Presence of Ge‐132

Using cyclic voltammetry, UV and 1H NMR spectroscopy, we have investigated the effect of 2‐carboxyethylgermanium (Ge‐132), the most common germanium‐containing dietary supplement, on the antioxidant activity of adrenaline in aqueous solutions. The complex formed by adrenaline and Ge‐132 is oxidizabl...

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Bibliographic Details
Published in:European journal of organic chemistry 2019-07, Vol.2019 (26), p.4128-4132
Main Authors: Filonova, Galina E., Nikolaevskaya, Elena N., Kansuzyan, Artem V., Krylova, Irina V., Egorov, Mikhail P., Jouikov, Viatcheslav V., Syroeshkin, Mikhail A.
Format: Article
Language:English
Subjects:
Adrenaline
Antioxidants
Aqueous solutions
Chemical Sciences
Complex formation
Cyclic voltammetry
Germanium
NMR spectroscopy
Organic chemistry
Oxidation
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Summary:Using cyclic voltammetry, UV and 1H NMR spectroscopy, we have investigated the effect of 2‐carboxyethylgermanium (Ge‐132), the most common germanium‐containing dietary supplement, on the antioxidant activity of adrenaline in aqueous solutions. The complex formed by adrenaline and Ge‐132 is oxidizable at 400 mV more positive potentials compared to non‐coordinated adrenaline which corresponds to its 9 kcal/mol more difficult oxidation. An equilibrium constant of the complex formation was estimated (1300 m–1). It was shown that at the concentrations
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201900331