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Effects of long-term methylphenidate treatment in adolescent and adult rats on hippocampal shape, functional connectivity and adult neurogenesis
Highlights • Methylphenidate (MPH) has different effects in young vs. adult rats. • MPH impairs object recognition in adolescent rats, but not adults. • MPH induces depressive-like behavior in adult rats, but not adolescent rats. • MPH induces opposite effects on neurogenesis, and hippocampal shape....
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Published in: | Neuroscience 2015-11, Vol.309, p.243-258 |
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Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Highlights • Methylphenidate (MPH) has different effects in young vs. adult rats. • MPH impairs object recognition in adolescent rats, but not adults. • MPH induces depressive-like behavior in adult rats, but not adolescent rats. • MPH induces opposite effects on neurogenesis, and hippocampal shape. • These findings are highly relevant for patients treated with MPH for attention deficit hyperactivity disorder (ADHD). |
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ISSN: | 0306-4522 1873-7544 |
DOI: | 10.1016/j.neuroscience.2015.04.044 |