Loading…

Effects of long-term methylphenidate treatment in adolescent and adult rats on hippocampal shape, functional connectivity and adult neurogenesis

Highlights • Methylphenidate (MPH) has different effects in young vs. adult rats. • MPH impairs object recognition in adolescent rats, but not adults. • MPH induces depressive-like behavior in adult rats, but not adolescent rats. • MPH induces opposite effects on neurogenesis, and hippocampal shape....

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience 2015-11, Vol.309, p.243-258
Main Authors: van der Marel, K, Bouet, V, Meerhoff, G.F, Freret, T, Boulouard, M, Dauphin, F, Klomp, A, Lucassen, P.J, Homberg, J.R, Dijkhuizen, R.M, Reneman, L
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Methylphenidate (MPH) has different effects in young vs. adult rats. • MPH impairs object recognition in adolescent rats, but not adults. • MPH induces depressive-like behavior in adult rats, but not adolescent rats. • MPH induces opposite effects on neurogenesis, and hippocampal shape. • These findings are highly relevant for patients treated with MPH for attention deficit hyperactivity disorder (ADHD).
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.04.044