The IGHG3 gene shows a structural polymorphism characterized by different hinge lengths : sequence of a new 2-exon hinge gene

Four of the five human IGHG genes (G1, GP, G2, and G4) display a hinge region consisting of a unique exon. In contrast, IGHG3 exhibits a different structure in which the hinge is constituted by four or, less frequently, three exons. We report here the nucleotide sequence of a new 2-exon hinge G3 gen...

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Bibliographic Details
Published in:Human genetics 1997-01, Vol.99 (1), p.138-141
Main Authors: DARD, P, HUCK, S, FRIPPIAT, J.-P, LEFRANC, G, LAGANEY, A, LEFRANC, M.-P, SANCHEZ-MAZAS, A
Format: Article
Language:English
Subjects:
B-Lymphocytes
Base Sequence
Biochemistry, Molecular Biology
Biological and medical sciences
Cell Line
Classical genetics, quantitative genetics, hybrids
DNA Primers
Ethnic Groups - genetics
Exons
Fundamental and applied biological sciences. Psychology
Genes, Immunoglobulin
Genetics of eukaryotes. Biological and molecular evolution
Hinge Exons
Homozygote
Human
Humans
Immunoglobulin G - genetics
Immunoglobulin Heavy Chains - genetics
Life Sciences
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
Polymorphism, Genetic
Restriction Mapping
Senegal
Sequence Deletion
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Summary:Four of the five human IGHG genes (G1, GP, G2, and G4) display a hinge region consisting of a unique exon. In contrast, IGHG3 exhibits a different structure in which the hinge is constituted by four or, less frequently, three exons. We report here the nucleotide sequence of a new 2-exon hinge G3 gene found in a Mandenka individual from Eastern Senegal. A comparison of this sequence with that of 4-exon and 3-exon hinge G3 genes suggests that the 3-exon and 2-exon hinge forms arose independently by deletion events in a 4-exon hinge gene.
ISSN:0340-6717
1432-1203
DOI:10.1007/s004390050328