Assembly of Double-Hydrophilic Block Copolymers Triggered by Gadolinium Ions: New Colloidal MRI Contrast Agents

Mixing double-hydrophilic block copolymers containing a poly­(acrylic acid) block with gadolinium ions in water leads to the spontaneous formation of polymeric nanoparticles. With an average diameter near 20 nm, the nanoparticles are exceptionally stable, even after dilution and over a large range o...

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Bibliographic Details
Published in:Nano letters 2016-07, Vol.16 (7), p.4069-4073
Main Authors: Frangville, Camille, Li, Yichen, Billotey, Claire, Talham, Daniel R, Taleb, Jacqueline, Roux, Patrick, Marty, Jean-Daniel, Mingotaud, Christophe
Format: Article
Language:English
Subjects:
Chemical Sciences
Condensed Matter
Materials Science
Physics
Polymers
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Summary:Mixing double-hydrophilic block copolymers containing a poly­(acrylic acid) block with gadolinium ions in water leads to the spontaneous formation of polymeric nanoparticles. With an average diameter near 20 nm, the nanoparticles are exceptionally stable, even after dilution and over a large range of pH and ionic strength. High magnetic relaxivities were measured in vitro for these biocompatible colloids, and in vivo magnetic resonance imaging on rats demonstrates the potential utility of such polymeric assemblies.
ISSN:1530-6984
1530-6992
DOI:10.1021/acs.nanolett.6b00664