Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA

The recent development of biohybrid catalytic systems has allowed synthetic chemists to reach high levels of selectivity on a wide variety of valuable synthetic transformations. In this context, DNA-based catalysts have emerged as particularly appealing tools. Interestingly, while long RNA sequences...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (55), p.864-867
Main Authors: Duchemin, Nicolas, Benedetti, Erica, Bethge, Lucas, Vonhoff, Stefan, Klussmann, Sven, Vasseur, Jean-Jacques, Cossy, Janine, Smietana, Michael, Arseniyadis, Stellios
Format: Article
Language:English
Subjects:
Alkylation
Asymmetry
Biocatalysis
Biochemistry
Catalysis
Catalysts
Chemical Sciences
Chemists
Gene sequencing
Medicinal Chemistry
Nucleic Acid Conformation
Organic chemistry
Ribonucleic acids
RNA, Catalytic - chemistry
RNA, Catalytic - metabolism
Solvents - chemistry
Transformations
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The recent development of biohybrid catalytic systems has allowed synthetic chemists to reach high levels of selectivity on a wide variety of valuable synthetic transformations. In this context, DNA-based catalysts have emerged as particularly appealing tools. Interestingly, while long RNA sequences (ribozymes) are known to catalyse specific biochemical reactions with remarkable efficiencies, RNA-based catalysts involving a catalytically active metal complex interacting in a non-covalent fashion with short sequences have never been evaluated to date. We report here our results, which have led to the first example involving a short RNA-based catalyst. We report here the first example of an RNA-based catalyst involving a catalytically active metal complex interacting in a non-covalent fashion with short RNA sequences.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc03540j