Adult sinonasal soft tissue sarcoma: Analysis of 48 cases from the French Sarcoma Group database

Objective The aim of this study was to determine the frequency of primary sinonasal adult sarcoma, identify histological subtypes, and analyze prognostic factors. Study Design Retrospective review. Method Forty‐eight adult sinonasal sarcomas included in the French Sarcoma Group database (Conticabase...

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Bibliographic Details
Published in:The Laryngoscope 2015-03, Vol.125 (3), p.615-623
Main Authors: Szablewski, Vanessa, Neuville, Agnès, Terrier, Philippe, Laé, Marick, Schaub, Roxane, Garrel, Renaud, Coindre, Jean-Michel, Costes, Valérie
Format: Article
Language:English
Subjects:
Adolescent
Adult
adults
Aged
Disease-Free Survival
Female
Follow-Up Studies
France - epidemiology
Human health and pathology
Humans
Incidence
Life Sciences
Male
Middle Aged
Neoplasm Staging
Nose Neoplasms - diagnosis
Nose Neoplasms - epidemiology
Paranasal Sinus Neoplasms - diagnosis
Paranasal Sinus Neoplasms - epidemiology
Prognosis
Retrospective Studies
rhabdomyosarcoma
Sarcoma - diagnosis
Sarcoma - epidemiology
sinonasal tract
soft tissue sarcoma
Survival Rate - trends
Young Adult
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Summary:Objective The aim of this study was to determine the frequency of primary sinonasal adult sarcoma, identify histological subtypes, and analyze prognostic factors. Study Design Retrospective review. Method Forty‐eight adult sinonasal sarcomas included in the French Sarcoma Group database (Conticabase) were reviewed. Results The most frequent tumor types were alveolar rhabdomyosarcoma (33.3%), embryonal rhabdomyosarcoma (14,6%), unclassified sarcoma (14.6%), and leiomyosarcoma (12.5%). All round cell tumors were rhabdomyosarcomas. The 5‐year overall survival (OS), metastasis‐free survival (MFS), and local recurrence‐free survival (LRFS) rates were 62.3%, 73%, and 88.8%, respectively. Histotype was a prognostic factor for OS, MFS, and LRFS, with the worst prognosis associated with rhabdomyosarcomas, regardless of the subtype. The tumor grade influenced the OS and MFS. Surgery was a predictive factor for a complete response. Conclusions These results suggest that sinonasal tract should be considered as an unfavorable site for rhabdomyosarcoma. Moreover, surgery should always be considered in treatment. Level of Evidence N/A. Laryngoscope, 125:615–623, 2015
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.24910