Rearing with artificially scented mothers attenuates conditioned odor aversion in adulthood but not its amygdala dependency

• Published in: Behavioural brain research 2009-03, Vol.198 (2), p.313-320
• Main Authors: Sevelinges, Yannick, Lévy, Frédéric, Mouly, Anne-Marie, Ferreira, Guillaume
• Format: Article
• Language: English
• Subjects: Age Factors; Amygdala - physiology; Animals; Animals, Newborn; Association Learning - physiology; Avoidance Learning - physiology; Behavioral psychophysiology; Biological and medical sciences; Conditioning, Classical - physiology; Early olfactory preference; Female; Food memory; Food Preferences - psychology; Fundamental and applied biological sciences. Psychology; Juvenile; Learning; Life Sciences; Male; Memory - physiology; Mother-Child Relations; Musa; Neurons and Cognition; Odorants; Pregnancy; Prunus dulcis; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rat; Rats; Rats, Wistar; Smell - physiology
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2008.11.003

The aim of the present study was to investigate whether neonatal odor experience associated with the mother affects food avoidance learning and basolateral amygdala (BLA) involvement in adulthood. Odorization of mother's nipples with banana or almond solutions from birth to weaning resulted in an impairment at adulthood of conditioned odor aversion (COA). These effects were specific to the early-experienced odor since no deficit was observed for COA to a novel odor (Experiment 1). In contrast, mere exposure to an odor in the home cage instead of on mother's nipples induced no deficit in COA at adulthood (Experiment 2). Finally, transitory inactivation of the BLA during COA acquisition in adult animals impaired the normal COA of naïve animals but also the attenuated COA of rats with early odor experience on the mother (Experiment 3). These results demonstrate that neonatal odor experience associated with the mother promotes the acquisition of appetitive memories which can interfere with food avoidance learning in adulthood. They also suggest that this early experience did not modify the BLA involvement in learned aversion.