Halonium-Induced Polyene Cyclizations

Abstract This review covers the methods that chemists have developed to access halogenated polycyclic structures from polyenes, by emulating Nature’s enzymatic machineries. From pioneering studies to the most recent developments, the different strategies, whether based on the use of standard reagent...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2019-04, Vol.51 (8), p.1753-1769
Main Authors: D’Hollander, Agathe C. A., Peilleron, Laure, Grayfer, Tatyana D., Cariou, Kevin
Format: Article
Language:English
Subjects:
Chemical Sciences
Organic chemistry
short review
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Summary:Abstract This review covers the methods that chemists have developed to access halogenated polycyclic structures from polyenes, by emulating Nature’s enzymatic machineries. From pioneering studies to the most recent developments, the different strategies, whether based on the use of standard reagents or on the design of specific ones, will be presented. Finally, asymmetric reactions and applications for the total synthesis of natural products will be exposed. 1 Introduction 2 Pioneering Studies 3 Use of Specific Reagents 4 Use of N -Haloamides 5 Asymmetric Reactions 6 Total Synthesis of Halogenated Natural Products 7 Conclusion and Perspectives
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0037-1612254