Synthesis of isoindolo[1,3]benzoxazine derivatives through intramolecular arylation of N-acyliminium ions

[1,3]Benzoxazines annulated to isoindole as 3 and 4 have been synthesized in three steps from N‐chloromethylphthalimide 5 and substituted phenols 6. The key step was the acid‐catalyzed cyclization of ω‐carbinol lactams 8 and 9.

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 1998-11, Vol.35 (6), p.1477-1483
Main Authors: Hucher, Nicolas, Daïch, Adam, Decroix, Bernard
Format: Article
Language:English
Subjects:
Chemical Sciences
Organic chemistry
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Description
Summary:[1,3]Benzoxazines annulated to isoindole as 3 and 4 have been synthesized in three steps from N‐chloromethylphthalimide 5 and substituted phenols 6. The key step was the acid‐catalyzed cyclization of ω‐carbinol lactams 8 and 9.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570350644