Prenatal stress in rats predicts immobility behavior in the forced swim test

Prenatally-stressed (PS) rats are characterized by a general impairment of the hypothalamo-pituitary-adrenal (HPA) axis and sleep disturbances indicating that this model has face validity with some clinical features observed in a subpopulation of depressed patients. The prolonged corticosterone secr...

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Bibliographic Details
Published in:Brain research 2003-11, Vol.989 (2), p.246-251
Main Authors: Morley-Fletcher, S., Darnaudery, M., Koehl, M., Casolini, P., Van Reeth, O., Maccari, S.
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Antidepressive Agents, Tricyclic
Behavior, Animal
Corticosterone
Disease Models, Animal
Female
Immobilization
Life Sciences
Male
Neurons and Cognition
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Stress, Physiological
Swimming
Thiazepines
Time Factors
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Summary:Prenatally-stressed (PS) rats are characterized by a general impairment of the hypothalamo-pituitary-adrenal (HPA) axis and sleep disturbances indicating that this model has face validity with some clinical features observed in a subpopulation of depressed patients. The prolonged corticosterone secretion shown by PS rats in response to stress was positively correlated with an increased immobility behavior in the forced swim test. To investigate the predictive validity of this model, a separate group of animals was chronically treated with the antidepressant tianeptine (10 mg/kg i.p. for 21 days). Such chronic treatment reduced in PS rats immobility time in the forced swim test. These findings suggest that the PS rat is an interesting animal model for the evaluation of antidepressant treatment.
ISSN:0006-8993
0006-8993
DOI:10.1016/S0006-8993(03)03293-1