Parameters for Stable Water-in-Oil Lipiodol Emulsion for Liver Trans-Arterial Chemo-Eembolization

• Published in: Cardiovascular and interventional radiology 2017-12, Vol.40 (12), p.1927-1932
• Main Authors: Deschamps, F., Moine, L., Isoardo, T., Tselikas, L., Paci, A., Mir, L. M., Huang, N., Fattal, E., de Baère, T.
• Format: Article
• Language: English
• Subjects: Antibiotics, Antineoplastic - chemistry; Bioengineering; Biomaterials; Cardiology; Chemoembolization, Therapeutic; Coalescence; Coalescing; Doxorubicin; Doxorubicin - chemistry; Drug delivery systems; Embolization; Emulsions; Ethiodized Oil - chemistry; Imaging; Impact tests; Injection; Laboratory Investigation; Life Sciences; Light scattering; Liver; Liver cancer; Liver Neoplasms; Medicine; Medicine & Public Health; Nuclear Medicine; Oil; Radiology; Stability analysis; Syringes; Ultrasound; Water
• ISSN: 0174-1551; 1432-086X
• DOI: 10.1007/s00270-017-1763-5

Purpose Water-in-oil type and stability are important properties for Lipiodol emulsions during conventional trans-arterial chemo-embolization. Our purpose is to evaluate the influence of 3 technical parameters on those properties. Materials and Methods The Lipiodol emulsions have been formulated by repetitive back-and-forth pumping of two 10-ml syringes through a 3-way stopcock. Three parameters were compared: Lipiodol/doxorubicin ratio (2/1 vs. 3/1), doxorubicin concentration (10 vs. 20 mg/ml) and speed of incorporation of doxorubicin in Lipiodol (bolus vs. incremental vs. continuous). The percentage of water-in-oil emulsion obtained and the duration until complete coalescence (stability) for water-in-oil emulsions were, respectively, evaluated with the drop-test and static light scattering technique (Turbiscan). Results Among the 48 emulsions formulated, 32 emulsions (67%) were water-in-oil. The percentage of water-in-oil emulsions obtained was significantly higher for incremental (94%) and for continuous (100%) injections compared to bolus injection (6%) of doxorubicin. Emulsion type was neither influenced by Lipiodol/doxorubicin ratio nor by doxorubicin concentration. The mean stability of water-in-oil emulsions was 215 ± 257 min. The emulsions stability was significantly longer when formulated using continuous compared to incremental injection (326 ± 309 vs. 96 ± 101 min, p  = 0.018) and using 3/1 compared to 2/1 ratio of Lipiodol/doxorubicin (372 ± 276 vs. 47 ± 43 min, p  =