Elemental Sulfur/DMSO‐Promoted Multicomponent One‐pot Synthesis of Malonic Acid Derivatives from Maleic Anhydride and Amines

Malonic acid derivatives could be conveniently prepared with high degree of functional flexibility via redox condensation reactions between anhydride maleic, amines, elemental sulfur and DMSO as oxidant. This multicomponent decarboxylative transformation consists in a cascade of ring opening, decarb...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2019-06, Vol.361 (12), p.2864-2869
Main Authors: Nguyen, Le Anh, Retailleau, Pascal, Nguyen, Thanh Binh
Format: Article
Language:English
Subjects:
Amines
Anhydrides
Chemical Sciences
decarboxylation
Derivatives
DMSO
Maleic anhydride
multicomponent reactions
Organic chemistry
oxidative condensation
Ring opening
Sulfur
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Summary:Malonic acid derivatives could be conveniently prepared with high degree of functional flexibility via redox condensation reactions between anhydride maleic, amines, elemental sulfur and DMSO as oxidant. This multicomponent decarboxylative transformation consists in a cascade of ring opening, decarboxylative oxidative thioamidation at temperature as low as 50 °C.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201900160