Elemental Sulfur as Reaction Medium for the Synthesis of Fused Nitrogen Heterocycles by Oxidative Coupling between Cycloalkanones and Nitrogen Nucleophiles

Molten elemental sulfur was found to be an excellent reaction medium for oxidative coupling between bis‐aza nucleophiles and cycloalkanones to the fused diaza heterocycles. No extensive aromatization was observed when cyclohexanone was used. These reaction conditions tolerate a wide range of functio...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2017-11, Vol.359 (21), p.3843-3847
Main Authors: Nguyen, Thanh Binh, Retailleau, Pascal
Format: Article
Language:English
Subjects:
azaheterocycle
bis-aza-nucleophile
Chemical Sciences
Chemical synthesis
Coupling
cycloalkanone
Cyclohexanone
Elemental sulfur
Functional groups
Nucleophiles
Organic chemistry
Oxidation
oxidative coupling
Sulfur
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Summary:Molten elemental sulfur was found to be an excellent reaction medium for oxidative coupling between bis‐aza nucleophiles and cycloalkanones to the fused diaza heterocycles. No extensive aromatization was observed when cyclohexanone was used. These reaction conditions tolerate a wide range of functional groups and are applicable to oxidation sensitive o‐phenylenediamines.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201700919