Cisplatin chemotherapy induces odor perception changes in bronchial cancer patients

Abstract A study of olfactory function was performed in 15 bronchial cancer patients receiving cisplatin and 15 control subjects. Whereas odor detection and odor identification abilities were not influenced by the administration of cisplatin, a decrease in pleasantness was observed only for food odo...

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Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2013-10, Vol.82 (1), p.168-170
Main Authors: Joussain, P, Giboreau, A, Fontas, M, Laville, M, Hummel, T, Souquet, P.J, Bensafi, M
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Bronchial cancer
Bronchial Neoplasms - drug therapy
Case-Control Studies
Chemotherapy
Cisplatin
Cisplatin - adverse effects
Cisplatin - therapeutic use
Cognitive science
Food
Hematology, Oncology and Palliative Medicine
Humans
Male
Medical sciences
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Odorants
Olfaction
Olfaction Disorders - chemically induced
pleasantness
Pneumology
Pulmonary/Respiratory
Quality of Life
Smell - drug effects
Tumors
Tumors of the respiratory system and mediastinum
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Summary:Abstract A study of olfactory function was performed in 15 bronchial cancer patients receiving cisplatin and 15 control subjects. Whereas odor detection and odor identification abilities were not influenced by the administration of cisplatin, a decrease in pleasantness was observed only for food odors, and not for non-food odors. Taken as a whole, these findings suggest that cisplatin therapy in bronchial cancer patients impairs the pleasure of perceived food odors, which may account for disturbances in food intake and quality of life in this population.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2013.06.009