The effects of FG 7142 on sensory-specific satiety in rats

• Published in: Behavioural brain research 2010-05, Vol.209 (1), p.131-136
• Main Authors: Martire, Sarah I., Parkes, Shauna L., Westbrook, R. Frederick
• Format: Article
• Language: English
• Subjects: Animals; Appetite Depressants - pharmacology; Behavioral psychophysiology; Biological and medical sciences; Carbolines - pharmacology; Clusters; Cognitive science; Dietary Sucrose - administration & dosage; Feeding Behavior - drug effects; FG 7142; Food Preferences - drug effects; Fundamental and applied biological sciences. Psychology; GABA; Licks; Liking; Male; Neuroscience; Psychology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Wistar; Recognition (Psychology) - drug effects; Satiation - drug effects; Sensation - drug effects; Sensation - physiology; Sensory-specific satiety; Sucrose - administration & dosage; Sweetening Agents - administration & dosage; Wanting
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2010.01.034

Three experiments used intake, clusters, and licks per cluster to study the effects of the GABA inverse agonist, FG 7142, on sensory-specific satiety in rats. In Experiment 1, rats were offered one of two palatable solutions and 30 min later tested with the same or the other solution. Rats that received the same solution consumed less, exhibited fewer clusters, fewer licks per cluster and a more rapid decline in rate of licking than rats tested with the other solution. In Experiments 2 and 3, rats tested with the same solution under FG 7142 showed fewer clusters and fewer licks per cluster than vehicle rats. Rats tested with the other solution under FG 7142 showed fewer licks per cluster but more clusters than vehicle rats. The results were discussed in terms of the distinction between “liking” and “wanting” and the role of GABA in the former but not the latter.