Type III collagen mimetic peptides designed with anti- or pro-aggregant activities on human platelets

We report the synthesis of collagen related peptides containing the peptide sequence Lys-Hyp-Gly-Glu-Hyp-Gly-Pro-Lys. The α-triple helix peptides behave as type III collagen analogues supporting platelet aggregation, while the homotrimer which does not exhibit a triple-helical conformation inhibits...

Full description

Saved in:
Bibliographic Details
Published in:European journal of medicinal chemistry 2007-05, Vol.42 (5), p.694-701
Main Authors: Pires, Viviane, Pêcher, Julien, Da Nascimento, Sophie, Maurice, Pascal, Bonnefoy, Arnaud, Dassonville, Alexandra, Amant, Carole, Fauvel-Lafève, Françoise, Legrand, Chantal, Rochette, Jacques, Sonnet, Pascal
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Anti-aggregant and pro-aggregant activities
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Circular Dichroism
Collagen Type III - chemistry
Collagen Type III - pharmacology
Humans
Life Sciences
Medical sciences
Molecular Mimicry
Molecular Sequence Data
Nuclear Magnetic Resonance, Biomolecular
Peptide sequence Lys-Hyp-Gly-Glu-Hyp-Gly-Pro-Lys
Pharmacology. Drug treatments
Platelet Aggregation - drug effects
Spectrometry, Mass, Electrospray Ionization
TIIICBP
Type III collagen analogues
α-Triple helix peptides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report the synthesis of collagen related peptides containing the peptide sequence Lys-Hyp-Gly-Glu-Hyp-Gly-Pro-Lys. The α-triple helix peptides behave as type III collagen analogues supporting platelet aggregation, while the homotrimer which does not exhibit a triple-helical conformation inhibits type III collagen-induced human platelet aggregation. The incorporation of the octapeptide sequence in type III collagen mimetic peptides may lead to the loss of the anti-thrombotic activity for a pro-thrombotic one. [Display omitted]
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2006.12.018