Bacterial Iron Uptake Pathways: Gates for the Import of Bactericide Compounds

Bacterial resistance to most antibiotics in clinical use has reached alarming proportions. A challenge for modern medicine will be to discover new antibiotics or strategies to combat multidrug resistant bacteria, especially Gram-negative bacteria for which the situation is particularly critical. Vec...

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Bibliographic Details
Published in:Journal of medicinal chemistry 2017-06, Vol.60 (11), p.4573-4576
Main Authors: Schalk, Isabelle J, Mislin, Gaëtan L. A
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - pharmacology
Biochemistry, Molecular Biology
Iron - metabolism
Life Sciences
Siderophores
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Summary:Bacterial resistance to most antibiotics in clinical use has reached alarming proportions. A challenge for modern medicine will be to discover new antibiotics or strategies to combat multidrug resistant bacteria, especially Gram-negative bacteria for which the situation is particularly critical. Vectorization of bactericide compounds by siderophores (iron chelators produced by bacteria) is a promising strategy able to considerably increase the efficacy of drugs. Such a Trojan horse strategy can also extend activity of specific Gram-positive antibiotics to Gram-negative bacteria.
ISSN:0022-2623
1520-4804
DOI:10.1021/acs.jmedchem.7b00554