Complex HLA association in paraneoplastic cerebellar ataxia with anti-Yo antibodies

• Published in: Journal of neuroimmunology 2018-02, Vol.315, p.28-32
• Main Authors: Hillary, Ryan P., Ollila, Hanna M., Lin, Ling, Desestret, Virginie, Rogemond, Veronique, Picard, Geraldine, Small, Mathilde, Arnulf, Isabelle, Dauvilliers, Yves, Honnorat, Jerome, Mignot, Emmanuel
• Format: Article
• Language: English
• Subjects: Anti-Yo; Ataxia; Breast cancer; Life Sciences; Ovarian cancer; Paraneoplastic
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/j.jneuroim.2017.12.012

Anti-Yo paraneoplastic cerebellar degeneration (PCD) is a devastating autoimmune complication of gynecological cancers. We hypothesized that as for other autoimmune diseases, specific HLA haplotypes are associated. We conducted high resolution HLA typing of Class I/Class II in 40 cases versus ethnically matched controls. Three cases with anti-Yo antibodies and peripheral neuropathy were also included. We detected protective effects of DPA1*01:03~DPB1*04:01 (OR=0, p=0.0008), DRB1*04:01~DQA1*03:03(OR=0, p=0.0016) and DPA1*01:03~DPB1*04:01 (OR=0.35, p=0.0047) overall. Increased DRB1*13:01~DQA1*01:03~DQB1*06:03 was also found in PCD ovarian cases (OR=5.4, p=0.0016). These results suggest differential genetic susceptibility to anti-Yo per cancer and with a primary HLA Class II involvement. [Display omitted] •In this study, we found clear evidence of HLA allele association with anti Yo-PCD.•The strongest association identified a protective and susceptibility haplotype.•Another association also suggests CD8+ T or Natural Killer cell involvement.