Highly cohesive monolayers of lipid derivatives of colchicine: a dynamics study

Monolayers of lipid derivatives of colchicine spread at the air–water interface reach the thermodynamic equilibrium over an abnormally long period of time. Dynamics of this equilibration and the behavior of the film during compression–decompression cycles are observed by fluorescence microscopy. The...

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Bibliographic Details
Published in:Chemistry and physics of lipids 2002, Vol.114 (1), p.99-102
Main Authors: Mons, Stéphane, Salesse, Christian, Mioskowski, Charles, Lebeau, Luc
Format: Article
Language:English
Subjects:
Chemical Sciences
Colchicine
Colchicine - chemistry
Dimerization
Fluorescence microscopy
Fluorescent Dyes
Life Sciences
Lipid monolayer
Lipids - chemistry
Micelles
Microscopy, Fluorescence
Molecular Structure
Monolayer fluidity
Phosphatidylethanolamines
Structure-Activity Relationship
Surface Properties
Thermodynamics
Viscosity
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Summary:Monolayers of lipid derivatives of colchicine spread at the air–water interface reach the thermodynamic equilibrium over an abnormally long period of time. Dynamics of this equilibration and the behavior of the film during compression–decompression cycles are observed by fluorescence microscopy. The thermodynamically disfavored structures observed are unrelated to previously described unusual shapes in the liquid expanded-gas coexistence regions. The relation between the cholesterol-like effect of the colchicinoid moiety, its propensity to dimerize, and the high viscosity of the monolayer are discussed.
ISSN:0009-3084
1873-2941
DOI:10.1016/S0009-3084(01)00203-1