Tc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma

Mesothelin is a membrane-associated protein overexpressed in pancreatic ductal adenocarcinoma (PDAC). Some mesothelin-targeted therapies are in clinical development but the identification of patients eligible for such therapies is still challenging. The objective of this study was to perform the ima...

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Bibliographic Details
Published in:Cancers 2019-10, Vol.11 (10)
Main Authors: Montemagno, Christopher, Cassim, Shamir, Trichanh, Dimitry, Savary, Clara, Pouysségur, Jacques, Pagès, Gilles, Fagret, Daniel, Broisat, Alexis, Ghezzi, Catherine
Format: Article
Language:English
Subjects:
Life Sciences
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Summary:Mesothelin is a membrane-associated protein overexpressed in pancreatic ductal adenocarcinoma (PDAC). Some mesothelin-targeted therapies are in clinical development but the identification of patients eligible for such therapies is still challenging. The objective of this study was to perform the imaging of mesothelin in mice models of PDAC with a technetium-labeled anti-mesothelin single-domain antibody (Tc-A1).
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers11101531