Tc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma

Mesothelin is a membrane-associated protein overexpressed in pancreatic ductal adenocarcinoma (PDAC). Some mesothelin-targeted therapies are in clinical development but the identification of patients eligible for such therapies is still challenging. The objective of this study was to perform the ima...

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Published in:Cancers 2019-10, Vol.11 (10)
Main Authors: Montemagno, Christopher, Cassim, Shamir, Trichanh, Dimitry, Savary, Clara, Pouysségur, Jacques, Pagès, Gilles, Fagret, Daniel, Broisat, Alexis, Ghezzi, Catherine
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container_issue 10
container_start_page
container_title Cancers
container_volume 11
creator Montemagno, Christopher
Cassim, Shamir
Trichanh, Dimitry
Savary, Clara
Pouysségur, Jacques
Pagès, Gilles
Fagret, Daniel
Broisat, Alexis
Ghezzi, Catherine
description Mesothelin is a membrane-associated protein overexpressed in pancreatic ductal adenocarcinoma (PDAC). Some mesothelin-targeted therapies are in clinical development but the identification of patients eligible for such therapies is still challenging. The objective of this study was to perform the imaging of mesothelin in mice models of PDAC with a technetium-labeled anti-mesothelin single-domain antibody (Tc-A1).
doi_str_mv 10.3390/cancers11101531
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title Tc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma
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