Tributyltin Hydride in NMP-Promoted Reduction of Acid Chlorides to Aldehydes under Transition-Metal-Free Conditions

Abstract Tributyltin hydride in N-methyl-2-pyrrolidinone (NMP) was used for the partial reduction of various functionalized acid chlorides at room temperature. This transition-metal-free procedure allows the synthesis of a range of (hetero)aromatic- and aliphatic aldehydes in good to excellent yield...

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Bibliographic Details
Published in:Synlett 2010-04, Vol.2010 (7), p.1101-1103
Main Authors: Le Ménez, Patrick, Hamze, Abdallah, Provot, Olivier, Brion, Jean-Daniel, Alami, Mouâd
Format: Article
Language:English
Subjects:
Catalysis
Chemical Sciences
letter
Organic chemistry
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Summary:Abstract Tributyltin hydride in N-methyl-2-pyrrolidinone (NMP) was used for the partial reduction of various functionalized acid chlorides at room temperature. This transition-metal-free procedure allows the synthesis of a range of (hetero)aromatic- and aliphatic aldehydes in good to excellent yields.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0029-1219796