Alkylation of manganese(II) tetraphenylporphyrin by a synthetic antimalarial trioxane

The synthesis and the antimalarial activity of a new kind of polycyclic 1,2,4-trioxanes are reported. The alkylation of the heme model MnIITPP by the biologically active (IC 50 = 320 nmol L-1) hemiperketal 2 is presented.

Saved in:
Bibliographic Details
Published in:Organic & biomolecular chemistry 2003-08, Vol.1 (16), p.2859
Main Authors: Berrien, Jean-François, Provot, Olivier, Mayrargue, Joëlle, Coquillay, Michel, Cicéron, Liliane, Gay, Frédérick, Danis, Martin, Robert, Anne, Meunier, Bernard
Format: Article
Language:English
Subjects:
Alkylation
Animals
Antimalarials - chemical synthesis
Antimalarials - chemistry
Antimalarials - pharmacology
Chemical Sciences
Chloroquine - pharmacology
Crystallography, X-Ray
Heme - chemistry
Heterocyclic Compounds - chemical synthesis
Heterocyclic Compounds - chemistry
Heterocyclic Compounds - pharmacology
Inhibitory Concentration 50
Medicinal Chemistry
Metalloporphyrins - chemistry
Models, Chemical
Molecular Structure
Organic chemistry
Plasmodium falciparum - drug effects
Plasmodium falciparum - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The synthesis and the antimalarial activity of a new kind of polycyclic 1,2,4-trioxanes are reported. The alkylation of the heme model MnIITPP by the biologically active (IC 50 = 320 nmol L-1) hemiperketal 2 is presented.
ISSN:1477-0520
1477-0539
DOI:10.1039/b302835f