Nano-analytical characterization of endogenous minerals in healthy placental tissue: mineral distribution, composition and ultrastructure

Despite its crucial role, the placenta is the least understood human organ. Recent clinical studies indicate a direct association between placental calcification and maternal and offspring health. This study reveals distinct characteristics of minerals formed during gestational ageing using cutting-...

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Bibliographic Details
Published in:Analyst (London) 2019-11, Vol.144 (23), p.685-6857
Main Authors: Anthis, Alexandre H. C, Tsolaki, Elena, Didierlaurent, Louis, Staubli, Samuel, Zboray, Robert, Neels, Antonia, Dietrich, Dörthe, Manser, Pius, Desbiolles, Lotus May, Leschka, Sebastian, Wildermuth, Simon, Lehner, Sandro, Chavatte-Palmer, Pascale, Jochum, Wolfram, Wick, Peter, Dommann, Alex, Bürki-Turnherr, Tina, Fischer, Tina, Hornung, René, Bertazzo, Sergio, Herrmann, Inge K
Format: Article
Language:English
Subjects:
Animals
Calcification
Calcification, Physiologic - physiology
Cats
Dogs
Female
Horses
Humans
Life Sciences
Microscopy, Electron, Scanning
Minerals
Minerals - analysis
Minerals - chemistry
Minerals - metabolism
Placenta - metabolism
Placenta - ultrastructure
Pregnancy
Rabbits
Reproductive Biology
Sexual reproduction
Spectrum Analysis
Tomography, X-Ray Computed
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Summary:Despite its crucial role, the placenta is the least understood human organ. Recent clinical studies indicate a direct association between placental calcification and maternal and offspring health. This study reveals distinct characteristics of minerals formed during gestational ageing using cutting-edge nano-analytical characterization and paves the way for investigations focused on the identification of potential markers for disease risks in a clinical setting based on atypical placental mineral fingerprints. This study reveals distinct characteristics of minerals formed during gestational ageing using nano-analytical characterization, and paves the way for the identification of markers for disease risks based on atypical placental mineral fingerprints.
ISSN:0003-2654
1364-5528
DOI:10.1039/c9an01312a