The Golgi apparatus and cell polarity: Roles of the cytoskeleton, the Golgi matrix, and Golgi membranes

Membrane trafficking plays a crucial role in cell polarity by directing lipids and proteins to specific subcellular locations in the cell and sustaining a polarized state. The Golgi apparatus, the master organizer of membrane trafficking, can be subdivided into three layers that play different mecha...

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Bibliographic Details
Published in:Current opinion in cell biology 2020-02, Vol.62, p.104-113
Main Authors: Ravichandran, Yamini, Goud, Bruno, Manneville, Jean-Baptiste
Format: Article
Language:English
Subjects:
Actin
Cell migration
Cellular Biology
Centrosome
Forces
Golgin
Life Sciences
Mechanics
Microtubules
Signaling
Trafficking
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Summary:Membrane trafficking plays a crucial role in cell polarity by directing lipids and proteins to specific subcellular locations in the cell and sustaining a polarized state. The Golgi apparatus, the master organizer of membrane trafficking, can be subdivided into three layers that play different mechanical roles: a cytoskeletal layer, the so-called Golgi matrix, and the Golgi membranes. First, the outer regions of the Golgi apparatus interact with cytoskeletal elements, mainly actin and microtubules, which shape, position, and orient the organelle. Closer to the Golgi membranes, a matrix of long coiled–coiled proteins not only selectively captures transport intermediates but also participates in signaling events during polarization of membrane trafficking. Finally, the Golgi membranes themselves serve as active signaling platforms during cell polarity events. We review here the recent findings that link the Golgi apparatus to cell polarity, focusing on the roles of the cytoskeleton, the Golgi matrix, and the Golgi membranes.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2019.10.003