Synthesis and in vitro Trichomonacidal activities of some new dialkylperoxides and 1,2,4-trioxanes

Two series of three trioxanes and 18 disubstituted peroxides were synthesised and evaluated for their in vitro trichomonacidal activity against Trichomonas vaginalis. The most active compound, 2-methylprop-2-yl 2-methoxyeth-1-yl peroxide exhibited an IC 50 value of 1.0±0.2 μM whereas other dialkyl p...

Full description

Saved in:
Bibliographic Details
Published in:European journal of medicinal chemistry 2001-10, Vol.36 (10), p.837-842
Main Authors: Camuzat-Dedenis, Boris, Provot, Olivier, Cointeaux, Laure, Perroux, Viviane, Berrien, Jean-François, Bories, Christian, Loiseau, Philippe M, Mayrargue, Joëlle
Format: Article
Language:English
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Antiprotozoal Agents - chemical synthesis
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - pharmacology
Biological and medical sciences
Chemical Sciences
Free Radicals - chemistry
Inhibitory Concentration 50
Medical sciences
Medicinal Chemistry
metronidazole
Organic chemistry
Oxidants - chemistry
peroxides
Peroxides - chemical synthesis
Pharmacology. Drug treatments
Trichomonas vaginalis
Trichomonas vaginalis - drug effects
trioxanes
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two series of three trioxanes and 18 disubstituted peroxides were synthesised and evaluated for their in vitro trichomonacidal activity against Trichomonas vaginalis. The most active compound, 2-methylprop-2-yl 2-methoxyeth-1-yl peroxide exhibited an IC 50 value of 1.0±0.2 μM whereas other dialkyl peroxides had various IC 50 values which could not be correlated to their molecule structure. The best compound was about five times more active than metronidazole. The amount of generated oxygen or free radicals cannot explain completely the activity suggesting another way of action for these compounds on T. vaginalis.
ISSN:0223-5234
1768-3254
DOI:10.1016/S0223-5234(01)01278-8