The Lens Opacities Classification System III Grading in Irradiated Uveal Melanomas to Characterize Proton Therapy-Induced Cataracts

To evaluate the use of the Lens Opacities Classification System III grading (LOCS III) for the characterization of radiation-induced cataract, and to correlate the proton beam projection onto the lens with cataract location and grade as defined by the LOCS III. Prospective, interventional case serie...

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Bibliographic Details
Published in:American journal of ophthalmology 2019-05, Vol.201, p.63-71
Main Authors: Mathis, Thibaud, Rosier, Laurence, Meniai, Fatima, Baillif, Stéphanie, Maschi, Celia, Herault, Joël, Caujolle, Jean-Pierre, Kodjikian, Laurent, Salleron, Julia, Thariat, Juliette
Format: Article
Language:English
Subjects:
Aged
Cataract - classification
Cataract - etiology
Cataracts
Classification
Engineering Sciences
Feasibility Studies
Female
Humans
Lens, Crystalline - radiation effects
Male
Materials
Melanoma
Melanoma - radiotherapy
Middle Aged
Ophthalmology
Optic nerve
Patients
Prognosis
Prospective Studies
Proton Therapy - adverse effects
Radiation Injuries - classification
Radiation Injuries - etiology
Radiation therapy
Radiotherapy Dosage
Ultrasonic imaging
Uveal Neoplasms - radiotherapy
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Summary:To evaluate the use of the Lens Opacities Classification System III grading (LOCS III) for the characterization of radiation-induced cataract, and to correlate the proton beam projection onto the lens with cataract location and grade as defined by the LOCS III. Prospective, interventional case series. Fifty-two consecutive patients with cataract following proton therapy were included. All cataracts were graded using LOCS III. Relationships between proton beam and cataract subtypes, as well as between dose, proportion of lens irradiated, and extent of cataracts, were assessed. Tumor diameter, volume, stage, and equatorial tumor location were associated with extent of posterior subcapsular cataracts (PSC) that were diagnosed at a median (interquartile range) 36 months (22;83) after treatment. In multivariate analysis, the tumor volume (P 
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2019.01.025