4-Hydroxytamoxifen Inhibits Proliferation of Multiple Myeloma Cells In vitro through Down-Regulation of c-Myc, Up-Regulation of p27Kip1, and Modulation of Bcl-2 Family Members

Cultured multiple myeloma cells were treated with various 4-OHT concentrations and the cellular response was studied: cell proliferation, cell viability, induction of apoptosis, caspase activities, and expression of signaling proteins. Multiple myeloma is an incurable B-cell malignancy requiring new...

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Bibliographic Details
Published in:Clinical cancer research 2005-03, Vol.11 (6), p.2345-2354
Main Authors: Gauduchon, Juliette, Gouilleux, Fabrice, Maillard, Sébastien, Marsaud, Véronique, Renoir, Jack-Michel, Sola, Brigitte
Format: Article
Language:English
Subjects:
Cancer
Life Sciences
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Summary:Cultured multiple myeloma cells were treated with various 4-OHT concentrations and the cellular response was studied: cell proliferation, cell viability, induction of apoptosis, caspase activities, and expression of signaling proteins. Multiple myeloma is an incurable B-cell malignancy requiring new therapeutic strategies. Our approach was to analyze the in vitro effects of a selective estrogen receptor modulator, 4-hydroxytamoxifen (4-OHT), on six multiple myeloma cell lines.
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.CCR-04-1668