Relationship between somatosensory deficit and brain somatosensory system after early brain lesion: A morphometric study

• Published in: European journal of paediatric neurology 2016-05, Vol.20 (3), p.403-411
• Main Authors: Perivier, Maximilien, Delion, Matthieu, Chinier, Eva, Loustau, Sebastien, Nguyen, Sylvie, Ter Minassian, Aram, Richard, Isabelle, Dinomais, Mickael
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Cerebral palsy; Cerebral Palsy - complications; Cerebral Palsy - pathology; Cerebral Palsy - physiopathology; Child; Female; Humans; Life Sciences; Magnetic Resonance Imaging; Male; Morphometry; MRI; Neurology; Pediatrics; Perceptual Disorders - etiology; Perceptual Disorders - pathology; Perceptual Disorders - physiopathology; Santé publique et épidémiologie; Sensory function; Somatosensory system; Touch Perception - physiology; Young Adult
• ISSN: 1090-3798; 1532-2130
• DOI: 10.1016/j.ejpn.2015.11.013

Abstract Cerebral Palsy (CP) is a group of permanent motor disorders due to non-progressive damage to the developing brain. Poor tactile discrimination is common in children with unilateral CP. Previous findings suggest the crucial role of structural integrity of the primary (S1) and secondary (S2) somatosensory areas located in the ipsilesional hemisphere for somatosensory function processing. However, no focus on the relationship between structural characteristics of ipsilesional S1 and S2 and tactile discrimination function in paretic hands has been proposed. Using structural MRI and a two-point discrimination assessment (2 PD), we explore this potential link in a group of 21 children (mean age 13 years and 7 months) with unilateral CP secondary to a periventricular white matter injury (PWMI) or middle cerebral artery infarct (MCA). For our whole sample there was a significant negative correlation between the 2 PD and the gray matter volume in the ipsilesional S2 (rho = −0.50 95% confidence interval [−0.76, −0.08], one-tailed p-value = 0.0109) and in the ipsilesional S1 (rho = −0.57, 95% confidence interval [−0.81, −0.19], one-tailed p-value = 0.0032). When studying these relationships with regard to the lesion types, we found these correlations were non-significant in the patients with PWMI but stronger in patients with MCA. According to our results, the degree of sensory impairment is related to the spared gray matter volume in ipsilesional S1 and S2 and is marked after an MCA stroke. Our work contributes to a better understanding of why some patients with CP have variable somatosensory deficit following an early brain lesion.