Contemporary assessment of the correlation between Bosniak classification and histological characteristics of surgically removed atypical renal cysts (UroCCR-12 study)

• Published in: World journal of urology 2018-10, Vol.36 (10), p.1643-1649
• Main Authors: Nouhaud, François-Xavier, Bernhard, Jean-Christophe, Bigot, Pierre, Khene, Zine-Eddine, Audenet, François, Lang, Herve, Bergerat, Sebastien, Fraisse, Guillaume, Grenier, Nicolas, Cornelis, François, Nedelcu, Cosmina, Béjar, Sofiane, Fromont-Hankard, Gaëlle, Allory, Yves, Lindner, Véronique, Verkarre, Virginie, Daniel, Laurent, Yacoub, Mokrane, Correas, Jean-Michel, Méjean, Arnaud, Rioux-Leclercq, Nathalie, Bensalah, Karim
• Format: Article
• Language: English
• Subjects: Aged; Cancer; Carcinoma, Renal Cell - classification; Carcinoma, Renal Cell - pathology; Carcinoma, Renal Cell - surgery; Clear cell-type renal cell carcinoma; Cysts; Cysts - classification; Cysts - pathology; Cysts - surgery; Female; Humans; Kidney cancer; Kidney Diseases, Cystic - classification; Kidney Diseases, Cystic - pathology; Kidney Diseases, Cystic - surgery; Kidney Neoplasms - classification; Kidney Neoplasms - pathology; Kidney Neoplasms - surgery; Life Sciences; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Nephrology; Oncology; Original Article; Prognosis; Retrospective Studies; Tomography, X-Ray Computed; Tumors; Urology
• ISSN: 0724-4983; 1433-8726
• DOI: 10.1007/s00345-018-2307-6

Purpose To evaluate and compare pathological characteristics of renal cysts Bosniak IIF, III and IV in light of recent histological classification. Patients and methods The French research network for kidney cancer UroCCR conducted a multicentre study on patients treated surgically for a renal cyst between 2007 and 2016. Independent radiological and centralized pathological reviews were performed for every patient. Pathological characteristics were compared to the Bosniak classification. Results Of a total 216 patients included, 175 (81.0%) tumours (90.9% of Bosniak IV, 69.8% of Bosniak III) were malignant or had a low malignant potential, with 60% of clear cell renal cell carcinoma (CCRCC), 24% of papillary RCC (PRCC) and 6.9% of multilocular cystic renal tumour of low malignant potential (MCRTLMP). Malignancies were mostly of low pT stage (86.4% of pT1–2), and low ISUP grade (68.0% of 1–2). Bosniak III cysts had a lower rate of CCRCC (46.7 vs. 67.3%), higher rate of PRCC (30 vs. 20.9%) and MCRTLMP (18.3 vs. 0.9%) compared to Bosniak IV ( p