Physiological Whole-Brain Distribution of [18F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis

Purpose 6-[ 18 F]fluoro- l -DOPA ([ 18 F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index...

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Bibliographic Details
Published in:Molecular imaging and biology 2019-06, Vol.21 (3), p.549-557
Main Authors: Toch, Sinn-Rithy, Poussier, Sylvain, Micard, Emilien, Bertaux, Marc, Van Der Gucht, Axel, Chevalier, Elodie, Marie, Pierre-Yves, Guedj, Eric, Verger, Antoine
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aged
Aged, 80 and over
Amino acids
Brain
Brain - diagnostic imaging
Brain - physiology
Brain mapping
Brain stem
Caudate nucleus
Cerebellum
Corpus Striatum - metabolism
Cortex (frontal)
Dihydroxyphenylalanine
Dihydroxyphenylalanine - analogs & derivatives
Dihydroxyphenylalanine - chemistry
Dopamine receptors
Emission analysis
Female
Fluorine isotopes
Gender
Human health and pathology
Humans
Imaging
Levodopa
Life Sciences
Linear Models
Male
Mapping
Medicine
Medicine & Public Health
Middle Aged
Neostriatum
Occipital lobe
Physiology
Positron emission
Positron emission tomography
Putamen
Quantitative analysis
Radiology
Research Article
Tissue Distribution
Tomography
Young Adult
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Summary:Purpose 6-[ 18 F]fluoro- l -DOPA ([ 18 F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [ 18 F]FDOPA, expressed relative to the occipital background level, varies according to age and gender. Procedures One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [ 18 F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of p  
ISSN:1536-1632
1860-2002
DOI:10.1007/s11307-018-1256-1