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Physiological Whole-Brain Distribution of [18F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis
Purpose 6-[ 18 F]fluoro- l -DOPA ([ 18 F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index...
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Published in: | Molecular imaging and biology 2019-06, Vol.21 (3), p.549-557 |
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container_title | Molecular imaging and biology |
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creator | Toch, Sinn-Rithy Poussier, Sylvain Micard, Emilien Bertaux, Marc Van Der Gucht, Axel Chevalier, Elodie Marie, Pierre-Yves Guedj, Eric Verger, Antoine |
description | Purpose
6-[
18
F]fluoro-
l
-DOPA ([
18
F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [
18
F]FDOPA, expressed relative to the occipital background level, varies according to age and gender.
Procedures
One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [
18
F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of
p
|
doi_str_mv | 10.1007/s11307-018-1256-1 |
format | article |
fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02479734v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2083713509</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-b8ca1b3d29f3ebef39281dae7d9a9f02bcfe281dfb21dda04c8b71284ef5e3c33</originalsourceid><addsrcrecordid>eNp9ks9u1DAQxiMEoqXwAFyQJS5wMPhPNrG5pS3bVlqpFVA4IGQ5yXjXxYm3dlK1L9LnrUNKkZDgZGvmN9-MPV-WvaTkHSWkfB8p5aTEhApM2aLA9FG2S0VBMCOEPU73BU_BgrOd7FmMF4TQkjL-NNvhqZovCrmb3Z5tbqL1zq9tox36tvEO8H7QtkeHNg7B1uNgfY-8Qd-pWP5YHp6eVeh8O-ifgE76Fq5RQj-B07-wwaNqDUj3LTqClA0fUi6ObojIBN8hjb76a3B4X0do0WfoLL4cdT_YIdVfAap67dI88Xn2xGgX4cX9uZedLz9-OTjGq9Ojk4NqhZuc5wOuRaNpzVsmDYcaDJdM0FZD2UotDWF1Y2CKmJrRttUkb0SdvkDkYBbAG873srez7kY7tQ220-FGeW3VcbVSU4ywvJQlz69oYt_M7Db4yxHioDobG3BO9-DHqBgRvKR8QWRCX_-FXvgxpLclirFCUJH29l-KJEbKQk5adKaa4GMMYB7mpERNNlCzDVSygZpsoKZRX90rj3UH7UPF770ngM1ATKl-DeFP63-r3gH1irxA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2081899699</pqid></control><display><type>article</type><title>Physiological Whole-Brain Distribution of [18F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis</title><source>Springer Link</source><creator>Toch, Sinn-Rithy ; Poussier, Sylvain ; Micard, Emilien ; Bertaux, Marc ; Van Der Gucht, Axel ; Chevalier, Elodie ; Marie, Pierre-Yves ; Guedj, Eric ; Verger, Antoine</creator><creatorcontrib>Toch, Sinn-Rithy ; Poussier, Sylvain ; Micard, Emilien ; Bertaux, Marc ; Van Der Gucht, Axel ; Chevalier, Elodie ; Marie, Pierre-Yves ; Guedj, Eric ; Verger, Antoine</creatorcontrib><description>Purpose
6-[
18
F]fluoro-
l
-DOPA ([
18
F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [
18
F]FDOPA, expressed relative to the occipital background level, varies according to age and gender.
Procedures
One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [
18
F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of
p
< 0.05 (corrected) and
p
< 0.005 (uncorrected,
k
cluster > 125).
Results
Striatal uptake indices were influenced by age, negatively for the caudate nucleus and positively for the putamen, as well as by gender, with a lower left putaminal uptake index in women. Extra-striatal uptake indices were influenced by age, negatively for the frontal cortex and brainstem and positively for the occipital cortex and cerebellum, as well as by gender (diffuse increase in women).
Conclusions
The uptake index of [
18
F]FDOPA exhibited significant physiological variations according to age and gender and should therefore be considered for PET interpretation.</description><identifier>ISSN: 1536-1632</identifier><identifier>EISSN: 1860-2002</identifier><identifier>DOI: 10.1007/s11307-018-1256-1</identifier><identifier>PMID: 30073569</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Amino acids ; Brain ; Brain - diagnostic imaging ; Brain - physiology ; Brain mapping ; Brain stem ; Caudate nucleus ; Cerebellum ; Corpus Striatum - metabolism ; Cortex (frontal) ; Dihydroxyphenylalanine ; Dihydroxyphenylalanine - analogs & derivatives ; Dihydroxyphenylalanine - chemistry ; Dopamine receptors ; Emission analysis ; Female ; Fluorine isotopes ; Gender ; Human health and pathology ; Humans ; Imaging ; Levodopa ; Life Sciences ; Linear Models ; Male ; Mapping ; Medicine ; Medicine & Public Health ; Middle Aged ; Neostriatum ; Occipital lobe ; Physiology ; Positron emission ; Positron emission tomography ; Putamen ; Quantitative analysis ; Radiology ; Research Article ; Tissue Distribution ; Tomography ; Young Adult</subject><ispartof>Molecular imaging and biology, 2019-06, Vol.21 (3), p.549-557</ispartof><rights>World Molecular Imaging Society 2018</rights><rights>Molecular Imaging and Biology is a copyright of Springer, (2018). All Rights Reserved.</rights><rights>Copyright Springer Nature B.V. 2019</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-b8ca1b3d29f3ebef39281dae7d9a9f02bcfe281dfb21dda04c8b71284ef5e3c33</citedby><cites>FETCH-LOGICAL-c434t-b8ca1b3d29f3ebef39281dae7d9a9f02bcfe281dfb21dda04c8b71284ef5e3c33</cites><orcidid>0000-0003-2194-0328 ; 0000-0001-9954-8866</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30073569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02479734$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Toch, Sinn-Rithy</creatorcontrib><creatorcontrib>Poussier, Sylvain</creatorcontrib><creatorcontrib>Micard, Emilien</creatorcontrib><creatorcontrib>Bertaux, Marc</creatorcontrib><creatorcontrib>Van Der Gucht, Axel</creatorcontrib><creatorcontrib>Chevalier, Elodie</creatorcontrib><creatorcontrib>Marie, Pierre-Yves</creatorcontrib><creatorcontrib>Guedj, Eric</creatorcontrib><creatorcontrib>Verger, Antoine</creatorcontrib><title>Physiological Whole-Brain Distribution of [18F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis</title><title>Molecular imaging and biology</title><addtitle>Mol Imaging Biol</addtitle><addtitle>Mol Imaging Biol</addtitle><description>Purpose
6-[
18
F]fluoro-
l
-DOPA ([
18
F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [
18
F]FDOPA, expressed relative to the occipital background level, varies according to age and gender.
Procedures
One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [
18
F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of
p
< 0.05 (corrected) and
p
< 0.005 (uncorrected,
k
cluster > 125).
Results
Striatal uptake indices were influenced by age, negatively for the caudate nucleus and positively for the putamen, as well as by gender, with a lower left putaminal uptake index in women. Extra-striatal uptake indices were influenced by age, negatively for the frontal cortex and brainstem and positively for the occipital cortex and cerebellum, as well as by gender (diffuse increase in women).
Conclusions
The uptake index of [
18
F]FDOPA exhibited significant physiological variations according to age and gender and should therefore be considered for PET interpretation.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amino acids</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiology</subject><subject>Brain mapping</subject><subject>Brain stem</subject><subject>Caudate nucleus</subject><subject>Cerebellum</subject><subject>Corpus Striatum - metabolism</subject><subject>Cortex (frontal)</subject><subject>Dihydroxyphenylalanine</subject><subject>Dihydroxyphenylalanine - analogs & derivatives</subject><subject>Dihydroxyphenylalanine - chemistry</subject><subject>Dopamine receptors</subject><subject>Emission analysis</subject><subject>Female</subject><subject>Fluorine isotopes</subject><subject>Gender</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Levodopa</subject><subject>Life Sciences</subject><subject>Linear Models</subject><subject>Male</subject><subject>Mapping</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neostriatum</subject><subject>Occipital lobe</subject><subject>Physiology</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Putamen</subject><subject>Quantitative analysis</subject><subject>Radiology</subject><subject>Research Article</subject><subject>Tissue Distribution</subject><subject>Tomography</subject><subject>Young Adult</subject><issn>1536-1632</issn><issn>1860-2002</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9ks9u1DAQxiMEoqXwAFyQJS5wMPhPNrG5pS3bVlqpFVA4IGQ5yXjXxYm3dlK1L9LnrUNKkZDgZGvmN9-MPV-WvaTkHSWkfB8p5aTEhApM2aLA9FG2S0VBMCOEPU73BU_BgrOd7FmMF4TQkjL-NNvhqZovCrmb3Z5tbqL1zq9tox36tvEO8H7QtkeHNg7B1uNgfY-8Qd-pWP5YHp6eVeh8O-ifgE76Fq5RQj-B07-wwaNqDUj3LTqClA0fUi6ObojIBN8hjb76a3B4X0do0WfoLL4cdT_YIdVfAap67dI88Xn2xGgX4cX9uZedLz9-OTjGq9Ojk4NqhZuc5wOuRaNpzVsmDYcaDJdM0FZD2UotDWF1Y2CKmJrRttUkb0SdvkDkYBbAG873srez7kY7tQ220-FGeW3VcbVSU4ywvJQlz69oYt_M7Db4yxHioDobG3BO9-DHqBgRvKR8QWRCX_-FXvgxpLclirFCUJH29l-KJEbKQk5adKaa4GMMYB7mpERNNlCzDVSygZpsoKZRX90rj3UH7UPF770ngM1ATKl-DeFP63-r3gH1irxA</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Toch, Sinn-Rithy</creator><creator>Poussier, Sylvain</creator><creator>Micard, Emilien</creator><creator>Bertaux, Marc</creator><creator>Van Der Gucht, Axel</creator><creator>Chevalier, Elodie</creator><creator>Marie, Pierre-Yves</creator><creator>Guedj, Eric</creator><creator>Verger, Antoine</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-2194-0328</orcidid><orcidid>https://orcid.org/0000-0001-9954-8866</orcidid></search><sort><creationdate>20190601</creationdate><title>Physiological Whole-Brain Distribution of [18F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis</title><author>Toch, Sinn-Rithy ; Poussier, Sylvain ; Micard, Emilien ; Bertaux, Marc ; Van Der Gucht, Axel ; Chevalier, Elodie ; Marie, Pierre-Yves ; Guedj, Eric ; Verger, Antoine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-b8ca1b3d29f3ebef39281dae7d9a9f02bcfe281dfb21dda04c8b71284ef5e3c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amino acids</topic><topic>Brain</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - physiology</topic><topic>Brain mapping</topic><topic>Brain stem</topic><topic>Caudate nucleus</topic><topic>Cerebellum</topic><topic>Corpus Striatum - metabolism</topic><topic>Cortex (frontal)</topic><topic>Dihydroxyphenylalanine</topic><topic>Dihydroxyphenylalanine - analogs & derivatives</topic><topic>Dihydroxyphenylalanine - chemistry</topic><topic>Dopamine receptors</topic><topic>Emission analysis</topic><topic>Female</topic><topic>Fluorine isotopes</topic><topic>Gender</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Levodopa</topic><topic>Life Sciences</topic><topic>Linear Models</topic><topic>Male</topic><topic>Mapping</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neostriatum</topic><topic>Occipital lobe</topic><topic>Physiology</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Putamen</topic><topic>Quantitative analysis</topic><topic>Radiology</topic><topic>Research Article</topic><topic>Tissue Distribution</topic><topic>Tomography</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toch, Sinn-Rithy</creatorcontrib><creatorcontrib>Poussier, Sylvain</creatorcontrib><creatorcontrib>Micard, Emilien</creatorcontrib><creatorcontrib>Bertaux, Marc</creatorcontrib><creatorcontrib>Van Der Gucht, Axel</creatorcontrib><creatorcontrib>Chevalier, Elodie</creatorcontrib><creatorcontrib>Marie, Pierre-Yves</creatorcontrib><creatorcontrib>Guedj, Eric</creatorcontrib><creatorcontrib>Verger, Antoine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Molecular imaging and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toch, Sinn-Rithy</au><au>Poussier, Sylvain</au><au>Micard, Emilien</au><au>Bertaux, Marc</au><au>Van Der Gucht, Axel</au><au>Chevalier, Elodie</au><au>Marie, Pierre-Yves</au><au>Guedj, Eric</au><au>Verger, Antoine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physiological Whole-Brain Distribution of [18F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis</atitle><jtitle>Molecular imaging and biology</jtitle><stitle>Mol Imaging Biol</stitle><addtitle>Mol Imaging Biol</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>21</volume><issue>3</issue><spage>549</spage><epage>557</epage><pages>549-557</pages><issn>1536-1632</issn><eissn>1860-2002</eissn><abstract>Purpose
6-[
18
F]fluoro-
l
-DOPA ([
18
F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [
18
F]FDOPA, expressed relative to the occipital background level, varies according to age and gender.
Procedures
One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [
18
F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of
p
< 0.05 (corrected) and
p
< 0.005 (uncorrected,
k
cluster > 125).
Results
Striatal uptake indices were influenced by age, negatively for the caudate nucleus and positively for the putamen, as well as by gender, with a lower left putaminal uptake index in women. Extra-striatal uptake indices were influenced by age, negatively for the frontal cortex and brainstem and positively for the occipital cortex and cerebellum, as well as by gender (diffuse increase in women).
Conclusions
The uptake index of [
18
F]FDOPA exhibited significant physiological variations according to age and gender and should therefore be considered for PET interpretation.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30073569</pmid><doi>10.1007/s11307-018-1256-1</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2194-0328</orcidid><orcidid>https://orcid.org/0000-0001-9954-8866</orcidid></addata></record> |
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issn | 1536-1632 1860-2002 |
language | eng |
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subjects | Adult Age Age Factors Aged Aged, 80 and over Amino acids Brain Brain - diagnostic imaging Brain - physiology Brain mapping Brain stem Caudate nucleus Cerebellum Corpus Striatum - metabolism Cortex (frontal) Dihydroxyphenylalanine Dihydroxyphenylalanine - analogs & derivatives Dihydroxyphenylalanine - chemistry Dopamine receptors Emission analysis Female Fluorine isotopes Gender Human health and pathology Humans Imaging Levodopa Life Sciences Linear Models Male Mapping Medicine Medicine & Public Health Middle Aged Neostriatum Occipital lobe Physiology Positron emission Positron emission tomography Putamen Quantitative analysis Radiology Research Article Tissue Distribution Tomography Young Adult |
title | Physiological Whole-Brain Distribution of [18F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis |
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