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Physiological Whole-Brain Distribution of [18F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis

Purpose 6-[ 18 F]fluoro- l -DOPA ([ 18 F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index...

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Published in:Molecular imaging and biology 2019-06, Vol.21 (3), p.549-557
Main Authors: Toch, Sinn-Rithy, Poussier, Sylvain, Micard, Emilien, Bertaux, Marc, Van Der Gucht, Axel, Chevalier, Elodie, Marie, Pierre-Yves, Guedj, Eric, Verger, Antoine
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cited_by cdi_FETCH-LOGICAL-c434t-b8ca1b3d29f3ebef39281dae7d9a9f02bcfe281dfb21dda04c8b71284ef5e3c33
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container_title Molecular imaging and biology
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creator Toch, Sinn-Rithy
Poussier, Sylvain
Micard, Emilien
Bertaux, Marc
Van Der Gucht, Axel
Chevalier, Elodie
Marie, Pierre-Yves
Guedj, Eric
Verger, Antoine
description Purpose 6-[ 18 F]fluoro- l -DOPA ([ 18 F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [ 18 F]FDOPA, expressed relative to the occipital background level, varies according to age and gender. Procedures One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [ 18 F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of p  
doi_str_mv 10.1007/s11307-018-1256-1
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Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [ 18 F]FDOPA, expressed relative to the occipital background level, varies according to age and gender. Procedures One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [ 18 F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of p  &lt; 0.05 (corrected) and p  &lt; 0.005 (uncorrected, k cluster &gt; 125). Results Striatal uptake indices were influenced by age, negatively for the caudate nucleus and positively for the putamen, as well as by gender, with a lower left putaminal uptake index in women. Extra-striatal uptake indices were influenced by age, negatively for the frontal cortex and brainstem and positively for the occipital cortex and cerebellum, as well as by gender (diffuse increase in women). Conclusions The uptake index of [ 18 F]FDOPA exhibited significant physiological variations according to age and gender and should therefore be considered for PET interpretation.</description><identifier>ISSN: 1536-1632</identifier><identifier>EISSN: 1860-2002</identifier><identifier>DOI: 10.1007/s11307-018-1256-1</identifier><identifier>PMID: 30073569</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Amino acids ; Brain ; Brain - diagnostic imaging ; Brain - physiology ; Brain mapping ; Brain stem ; Caudate nucleus ; Cerebellum ; Corpus Striatum - metabolism ; Cortex (frontal) ; Dihydroxyphenylalanine ; Dihydroxyphenylalanine - analogs &amp; derivatives ; Dihydroxyphenylalanine - chemistry ; Dopamine receptors ; Emission analysis ; Female ; Fluorine isotopes ; Gender ; Human health and pathology ; Humans ; Imaging ; Levodopa ; Life Sciences ; Linear Models ; Male ; Mapping ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Neostriatum ; Occipital lobe ; Physiology ; Positron emission ; Positron emission tomography ; Putamen ; Quantitative analysis ; Radiology ; Research Article ; Tissue Distribution ; Tomography ; Young Adult</subject><ispartof>Molecular imaging and biology, 2019-06, Vol.21 (3), p.549-557</ispartof><rights>World Molecular Imaging Society 2018</rights><rights>Molecular Imaging and Biology is a copyright of Springer, (2018). All Rights Reserved.</rights><rights>Copyright Springer Nature B.V. 2019</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-b8ca1b3d29f3ebef39281dae7d9a9f02bcfe281dfb21dda04c8b71284ef5e3c33</citedby><cites>FETCH-LOGICAL-c434t-b8ca1b3d29f3ebef39281dae7d9a9f02bcfe281dfb21dda04c8b71284ef5e3c33</cites><orcidid>0000-0003-2194-0328 ; 0000-0001-9954-8866</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30073569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02479734$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Toch, Sinn-Rithy</creatorcontrib><creatorcontrib>Poussier, Sylvain</creatorcontrib><creatorcontrib>Micard, Emilien</creatorcontrib><creatorcontrib>Bertaux, Marc</creatorcontrib><creatorcontrib>Van Der Gucht, Axel</creatorcontrib><creatorcontrib>Chevalier, Elodie</creatorcontrib><creatorcontrib>Marie, Pierre-Yves</creatorcontrib><creatorcontrib>Guedj, Eric</creatorcontrib><creatorcontrib>Verger, Antoine</creatorcontrib><title>Physiological Whole-Brain Distribution of [18F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis</title><title>Molecular imaging and biology</title><addtitle>Mol Imaging Biol</addtitle><addtitle>Mol Imaging Biol</addtitle><description>Purpose 6-[ 18 F]fluoro- l -DOPA ([ 18 F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [ 18 F]FDOPA, expressed relative to the occipital background level, varies according to age and gender. Procedures One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [ 18 F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of p  &lt; 0.05 (corrected) and p  &lt; 0.005 (uncorrected, k cluster &gt; 125). Results Striatal uptake indices were influenced by age, negatively for the caudate nucleus and positively for the putamen, as well as by gender, with a lower left putaminal uptake index in women. Extra-striatal uptake indices were influenced by age, negatively for the frontal cortex and brainstem and positively for the occipital cortex and cerebellum, as well as by gender (diffuse increase in women). Conclusions The uptake index of [ 18 F]FDOPA exhibited significant physiological variations according to age and gender and should therefore be considered for PET interpretation.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amino acids</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiology</subject><subject>Brain mapping</subject><subject>Brain stem</subject><subject>Caudate nucleus</subject><subject>Cerebellum</subject><subject>Corpus Striatum - metabolism</subject><subject>Cortex (frontal)</subject><subject>Dihydroxyphenylalanine</subject><subject>Dihydroxyphenylalanine - analogs &amp; derivatives</subject><subject>Dihydroxyphenylalanine - chemistry</subject><subject>Dopamine receptors</subject><subject>Emission analysis</subject><subject>Female</subject><subject>Fluorine isotopes</subject><subject>Gender</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Levodopa</subject><subject>Life Sciences</subject><subject>Linear Models</subject><subject>Male</subject><subject>Mapping</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Neostriatum</subject><subject>Occipital lobe</subject><subject>Physiology</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Putamen</subject><subject>Quantitative analysis</subject><subject>Radiology</subject><subject>Research Article</subject><subject>Tissue Distribution</subject><subject>Tomography</subject><subject>Young Adult</subject><issn>1536-1632</issn><issn>1860-2002</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9ks9u1DAQxiMEoqXwAFyQJS5wMPhPNrG5pS3bVlqpFVA4IGQ5yXjXxYm3dlK1L9LnrUNKkZDgZGvmN9-MPV-WvaTkHSWkfB8p5aTEhApM2aLA9FG2S0VBMCOEPU73BU_BgrOd7FmMF4TQkjL-NNvhqZovCrmb3Z5tbqL1zq9tox36tvEO8H7QtkeHNg7B1uNgfY-8Qd-pWP5YHp6eVeh8O-ifgE76Fq5RQj-B07-wwaNqDUj3LTqClA0fUi6ObojIBN8hjb76a3B4X0do0WfoLL4cdT_YIdVfAap67dI88Xn2xGgX4cX9uZedLz9-OTjGq9Ojk4NqhZuc5wOuRaNpzVsmDYcaDJdM0FZD2UotDWF1Y2CKmJrRttUkb0SdvkDkYBbAG873srez7kY7tQ220-FGeW3VcbVSU4ywvJQlz69oYt_M7Db4yxHioDobG3BO9-DHqBgRvKR8QWRCX_-FXvgxpLclirFCUJH29l-KJEbKQk5adKaa4GMMYB7mpERNNlCzDVSygZpsoKZRX90rj3UH7UPF770ngM1ATKl-DeFP63-r3gH1irxA</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Toch, Sinn-Rithy</creator><creator>Poussier, Sylvain</creator><creator>Micard, Emilien</creator><creator>Bertaux, Marc</creator><creator>Van Der Gucht, Axel</creator><creator>Chevalier, Elodie</creator><creator>Marie, Pierre-Yves</creator><creator>Guedj, Eric</creator><creator>Verger, Antoine</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-2194-0328</orcidid><orcidid>https://orcid.org/0000-0001-9954-8866</orcidid></search><sort><creationdate>20190601</creationdate><title>Physiological Whole-Brain Distribution of [18F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis</title><author>Toch, Sinn-Rithy ; 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Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [ 18 F]FDOPA, expressed relative to the occipital background level, varies according to age and gender. Procedures One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [ 18 F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of p  &lt; 0.05 (corrected) and p  &lt; 0.005 (uncorrected, k cluster &gt; 125). Results Striatal uptake indices were influenced by age, negatively for the caudate nucleus and positively for the putamen, as well as by gender, with a lower left putaminal uptake index in women. Extra-striatal uptake indices were influenced by age, negatively for the frontal cortex and brainstem and positively for the occipital cortex and cerebellum, as well as by gender (diffuse increase in women). Conclusions The uptake index of [ 18 F]FDOPA exhibited significant physiological variations according to age and gender and should therefore be considered for PET interpretation.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30073569</pmid><doi>10.1007/s11307-018-1256-1</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2194-0328</orcidid><orcidid>https://orcid.org/0000-0001-9954-8866</orcidid></addata></record>
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ispartof Molecular imaging and biology, 2019-06, Vol.21 (3), p.549-557
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subjects Adult
Age
Age Factors
Aged
Aged, 80 and over
Amino acids
Brain
Brain - diagnostic imaging
Brain - physiology
Brain mapping
Brain stem
Caudate nucleus
Cerebellum
Corpus Striatum - metabolism
Cortex (frontal)
Dihydroxyphenylalanine
Dihydroxyphenylalanine - analogs & derivatives
Dihydroxyphenylalanine - chemistry
Dopamine receptors
Emission analysis
Female
Fluorine isotopes
Gender
Human health and pathology
Humans
Imaging
Levodopa
Life Sciences
Linear Models
Male
Mapping
Medicine
Medicine & Public Health
Middle Aged
Neostriatum
Occipital lobe
Physiology
Positron emission
Positron emission tomography
Putamen
Quantitative analysis
Radiology
Research Article
Tissue Distribution
Tomography
Young Adult
title Physiological Whole-Brain Distribution of [18F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis
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