Antitumoral activity of quinoxaline derivatives: A systematic review

Cancer is a leading cause of death and a major health problem worldwide. While many effective anticancer agents are available, the majority of drugs currently on the market are not specific, raising issues like the common side effects of chemotherapy. However, recent research hold promise for the de...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2019-02, Vol.163, p.136-147
Main Authors: Montana, M., Mathias, F., Terme, T., Vanelle, P.
Format: Article
Language:English
Subjects:
Anticancer
Biological applications
Chemical Sciences
Chemistry
Kinase inhibitors
Quinoxaline
SAR
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Summary:Cancer is a leading cause of death and a major health problem worldwide. While many effective anticancer agents are available, the majority of drugs currently on the market are not specific, raising issues like the common side effects of chemotherapy. However, recent research hold promise for the development of more efficient and safer anticancer drugs. Quinoxaline and its derivatives are becoming recognized as a novel class of chemotherapeutic agents with activity against different tumors. The present review compiles and discusses studies concerning the therapeutic potential of the anticancer activity of quinoxaline derivatives, covering articles published between July 2013 and July 2018. [Display omitted] •Quinoxaline is a nitrogen containing a heterocyclic compound formed by the fusion of benzene and pyrazine.•Many drug candidates bearing quinoxaline moiety are currently under clinical trials for anticancer therapeutic purposes.•A systematic review on antitumoral activities linked to quinoxaline derivatives was carried out.•This review will be helpful for medicinal chemists in the development of useful anticancer therapeutics.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2018.11.059