Evaluation of surface deformability of lipid nanocapsules by drop tensiometer technique, and its experimental assessment by dialysis and tangential flow filtration

Deformability of nanoparticles might affect their behaviour at biological interfaces. Lipid nanocapsules (LNCs) are semi-solid particles resembling a hybrid of polymer nanoparticles and liposomes. Deformability of LNCs of different sizes was modelled by drop tensiometer technique. Two purification m...

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Bibliographic Details
Published in:International journal of pharmaceutics 2012-09, Vol.434 (1-2), p.460-467
Main Authors: Hirsjärvi, Samuli, Bastiat, Guillaume, Saulnier, Patrick, Benoît, Jean-Pierre
Format: Article
Language:English
Subjects:
Chemical Sciences
Dialysis
Drop tensiometer
Engineering Sciences
filtrates
Filtration
Life Sciences
Lipid nanocapsules
Lipids - chemistry
Materials
Membranes - metabolism
Molecular Weight
Nanocapsules
nanoparticles
Particle Size
Pharmaceutical sciences
polymers
Polymers - chemistry
purification methods
rheological properties
Rheology
Tangential flow filtration
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Summary:Deformability of nanoparticles might affect their behaviour at biological interfaces. Lipid nanocapsules (LNCs) are semi-solid particles resembling a hybrid of polymer nanoparticles and liposomes. Deformability of LNCs of different sizes was modelled by drop tensiometer technique. Two purification methods, dialysis and tangential flow filtration (TFF), were applied to study experimental behaviour and deformability of LNCs in order to evaluate if these properties contributed to membrane passing. Rheological parameters obtained from the drop tensiometer analysis suggested decreasing surface deformability of LNCs with increase in diameter. Dialysis results showed that up to 10% of LNCs can be lost during the process (e.g. membrane accumulation) but no clear evidence of the membrane passing was observed. Instead, LNCs with initial size and size distribution could be found in the TFF filtrate although molecular weight cut-off (MWCO) of the membrane used was smaller than the LNC diameter.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2012.06.019