Iodinated Metallacrowns: Toward Combined Bimodal Near‐Infrared and X‐Ray Contrast Imaging Agents

Multimodal probes capable of combining imaging modalities within a single molecule are in high demand today as they can provide information at both molecular and anatomical levels. Herein, a study was conducted on a series of gallium(III)/lanthanide(III) bis(12‐MC‐4) metallacrowns (MCs) with the gen...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry : a European journal 2020-01, Vol.26 (6), p.1274-1277
Main Authors: Lutter, Jacob C., Eliseeva, Svetlana V., Collet, Guillaume, Martinić, Ivana, Kampf, Jeff W., Schneider, Bernadette L., Carichner, Aidan, Sobilo, Julien, Lerondel, Stéphanie, Petoud, Stéphane, Pecoraro, Vincent L.
Format: Article
Language:English
Subjects:
Attenuation
Chemical Sciences
Chemistry
Computed tomography
Coordination chemistry
Gallium
Infrared imaging
lanthanides
Luminescence
metallacrowns
near-infrared
Optical properties
X-ray computed tomography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Multimodal probes capable of combining imaging modalities within a single molecule are in high demand today as they can provide information at both molecular and anatomical levels. Herein, a study was conducted on a series of gallium(III)/lanthanide(III) bis(12‐MC‐4) metallacrowns (MCs) with the general composition {Ln[12‐MCGaIIIN(shi)‐4]}2(iph)4 (Ln‐Ix, x=0, 4, 8, 12), where shi and iph are salicylhydroximate and isophthalate ligands, respectively, or their iodinated derivatives. For Yb‐Ix, the attenuation in X‐ray computed tomography (XCT) imaging and near‐infrared (NIR) luminescence properties can be finely tuned by controlled structural modifications based on iodo groups. Solutions of Yb‐Ix appear to be 22–40 times more efficient as XCT agents in comparison to the commercially available iobitridol, while providing an intense emission signal in the NIR range with total quantum yields up to 8.6 %, which are among the highest values reported so far. Therefore, these molecules are promising potential bimodal agents for combined NIR luminescence and XCT imaging. A new family of iodinated ytterbium(III)‐gallium(III) metallacrowns with tunable X‐Ray attenuation and near‐infrared luminescence has been created.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201905241