Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies

Highlights • Biofilms may have evolved as an adaptive response to environmental stresses. • Biofilm formation is a complex process involving sophisticated regulatory networks. • Biofilms are highly resistant to diverse antibiotics. • Resistance is adaptive and mediated through a plethora of molecula...

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Bibliographic Details
Published in:Current opinion in microbiology 2013-10, Vol.16 (5), p.580-589
Main Authors: de la Fuente-Núñez, César, Reffuveille, Fany, Fernández, Lucía, Hancock, Robert EW
Format: Article
Language:English
Subjects:
anaerobiosis
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
antibiotic resistance
antibiotics
Bacteria
Bacteria - growth & development
Bacterial Physiological Phenomena
Bacteriology
biofilm
Biofilms - drug effects
Biofilms - growth & development
defense mechanisms
Drug Resistance, Bacterial
heat
Life Sciences
Microbiology and Parasitology
Pathology
therapeutics
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Summary:Highlights • Biofilms may have evolved as an adaptive response to environmental stresses. • Biofilm formation is a complex process involving sophisticated regulatory networks. • Biofilms are highly resistant to diverse antibiotics. • Resistance is adaptive and mediated through a plethora of molecular mechanisms. • Potential new therapeutics that specifically target biofilms are under development.
ISSN:1369-5274
1879-0364
1369-5274
DOI:10.1016/j.mib.2013.06.013