Synthesis, characterization and biodistribution of a new technetium-99m complex with trimethylsilylmethylisonitrile. Comparison with 99mTc-TBI and 99mTc-MIBI

An isonitrile ligand with a silicium component was synthesized and a copper salt of this ligand was then used to form a 99mTc complex. We evaluated the physicochemical characteristics of the complex and its biodistribution in rat. The chemical properties, i.e. lipophilic affinity and charge, were co...

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Bibliographic Details
Published in:Nuclear medicine and biology 1995-07, Vol.22 (5), p.585-588
Main Authors: Bouquillon, S., Coulais, Y., Dartiguenave, M., Tafani, J.A.M., Guiraud, R.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chemical Phenomena
Chemical Sciences
Chemistry, Physical
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Contrast media. Radiopharmaceuticals
Coordination chemistry
Isotope Labeling
Ligands
Magnetic Resonance Spectroscopy
Male
Medical sciences
Nitriles - chemical synthesis
Nitriles - chemistry
Nitriles - pharmacokinetics
Organotechnetium Compounds - chemical synthesis
Organotechnetium Compounds - chemistry
Organotechnetium Compounds - pharmacokinetics
Pharmacology. Drug treatments
Rats
Rats, Wistar
Spectrophotometry, Ultraviolet
Technetium Tc 99m Sestamibi - chemistry
Tissue Distribution
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Summary:An isonitrile ligand with a silicium component was synthesized and a copper salt of this ligand was then used to form a 99mTc complex. We evaluated the physicochemical characteristics of the complex and its biodistribution in rat. The chemical properties, i.e. lipophilic affinity and charge, were comparable to those of other 99mTc complexes formed with similar isonitrile compounds ( 99mTc-MIBI and 99mTc-TBI). In contrast, the tissue biodistribution of this new technetium complex differed markedly, as it was mainly taken up in the liver and not at all in the heart.
ISSN:0969-8051
1872-9614
DOI:10.1016/0969-8051(95)00001-E