Th17 and cd24(hi)cd27(+) regulatory b lymphocytes are biomarkers of response to biologics in rheumatoid arthritis

The aim was to describe the regulatory B and T cells (Breg and Treg) and T helper 17 (Th17) lymphocytes before and under treatment with biologic drugs, and to assess their potential predictive value as biomarkers of response in rheumatoid arthritis (RA).This was a non-randomised, single-centre, pros...

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Bibliographic Details
Published in:Arthritis research & therapy 2017, Vol.19
Main Authors: Salomon, Sarah, Guignant, Caroline, Morel, Pierre, Flahaut, Gauthier, Brault, Clement, Gourguechon, Clement, Fardellone, Patrice, Marolleau, Jean-Pierre, Gubler, Brigitte, Goeb, Vincent
Format: Article
Language:English
Subjects:
Human health and pathology
Immunology
Immunotherapy
Life Sciences
Rhumatology and musculoskeletal system
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Summary:The aim was to describe the regulatory B and T cells (Breg and Treg) and T helper 17 (Th17) lymphocytes before and under treatment with biologic drugs, and to assess their potential predictive value as biomarkers of response in rheumatoid arthritis (RA).This was a non-randomised, single-centre, prospective study. Patients with active RA (American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) 2010) who required the initiation or switch to any biologic drug except rituximab were included. The main judgement criterion was the frequency and absolute number of CD24hi+hihihilow-++Thirty-one patients with RA and 17 controls were included. There was a reduction in T2/Breg frequency at M0 in patients (p 
ISSN:1478-6354
DOI:10.1186/s13075-017-1244-x