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Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla
Bio-guided fractionation of the roots of Paris polyphylla (Trilliaceae), based on inhibition of P-glycoprotein-mediated daunorubicin efflux in K562/R7 cell line, led to isolation and identification of the three saponins 3- O-Rha(1 → 2)[Ara(1 → 4)]Glc-pennogenine, gracillin and polyphyllin D, and the...
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| Published in: | Fitoterapia 2009, Vol.80 (1), p.39-42 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c424t-489fe6682dd72f3a1b971cd5cd85a2bd191eb7821368576bc062c168dea9f4d63 |
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| cites | cdi_FETCH-LOGICAL-c424t-489fe6682dd72f3a1b971cd5cd85a2bd191eb7821368576bc062c168dea9f4d63 |
| container_end_page | 42 |
| container_issue | 1 |
| container_start_page | 39 |
| container_title | Fitoterapia |
| container_volume | 80 |
| creator | Nguyen, Van Thi Bao Darbour, Nicole Bayet, Christine Doreau, Agnès Raad, Imad Phung, Binh Hoa Dumontet, Charles Di Pietro, Attilio Dijoux-Franca, Marie-Geneviève Guilet, David |
| description | Bio-guided fractionation of the roots of
Paris polyphylla (Trilliaceae), based on inhibition of P-glycoprotein-mediated daunorubicin efflux in K562/R7 cell line, led to isolation and identification of the three saponins 3-
O-Rha(1
→
2)[Ara(1
→
4)]Glc-pennogenine, gracillin and polyphyllin D, and the two ecdysteroids 20-hydroxyecdysone and pinnatasterone. These compounds were tested for multidrug reversion on P-glycoprotein (ABCB1) with both drug-selected and transfected cell lines, and also on Breast Cancer Resistance Protein (BCRP/ABCG2). By contrast to a weak efficiency on BCRP, the three saponins displayed significant effects as inhibitors of P-glycoprotein-mediated drug efflux. |
| doi_str_mv | 10.1016/j.fitote.2008.09.010 |
| format | article |
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Paris polyphylla (Trilliaceae), based on inhibition of P-glycoprotein-mediated daunorubicin efflux in K562/R7 cell line, led to isolation and identification of the three saponins 3-
O-Rha(1
→
2)[Ara(1
→
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Paris polyphylla (Trilliaceae), based on inhibition of P-glycoprotein-mediated daunorubicin efflux in K562/R7 cell line, led to isolation and identification of the three saponins 3-
O-Rha(1
→
2)[Ara(1
→
4)]Glc-pennogenine, gracillin and polyphyllin D, and the two ecdysteroids 20-hydroxyecdysone and pinnatasterone. These compounds were tested for multidrug reversion on P-glycoprotein (ABCB1) with both drug-selected and transfected cell lines, and also on Breast Cancer Resistance Protein (BCRP/ABCG2). By contrast to a weak efficiency on BCRP, the three saponins displayed significant effects as inhibitors of P-glycoprotein-mediated drug efflux.</description><subject>ABCB1</subject><subject>Analytical chemistry</subject><subject>BCRP (ABCG2)</subject><subject>Biological and medical sciences</subject><subject>Breast Cancer Resistance Protein</subject><subject>Chemical Sciences</subject><subject>Ecdysteroids</subject><subject>General pharmacology</subject><subject>Life Sciences</subject><subject>MDR</subject><subject>Medical sciences</subject><subject>Multidrug resistance</subject><subject>P-glycoprotein</subject><subject>Paris polyphylla</subject><subject>Pharmaceutical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Saponins</topic><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Van Thi Bao</creatorcontrib><creatorcontrib>Darbour, Nicole</creatorcontrib><creatorcontrib>Bayet, Christine</creatorcontrib><creatorcontrib>Doreau, Agnès</creatorcontrib><creatorcontrib>Raad, Imad</creatorcontrib><creatorcontrib>Phung, Binh Hoa</creatorcontrib><creatorcontrib>Dumontet, Charles</creatorcontrib><creatorcontrib>Di Pietro, Attilio</creatorcontrib><creatorcontrib>Dijoux-Franca, Marie-Geneviève</creatorcontrib><creatorcontrib>Guilet, David</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Fitoterapia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, Van Thi Bao</au><au>Darbour, Nicole</au><au>Bayet, Christine</au><au>Doreau, Agnès</au><au>Raad, Imad</au><au>Phung, Binh Hoa</au><au>Dumontet, Charles</au><au>Di Pietro, Attilio</au><au>Dijoux-Franca, Marie-Geneviève</au><au>Guilet, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla</atitle><jtitle>Fitoterapia</jtitle><date>2009</date><risdate>2009</risdate><volume>80</volume><issue>1</issue><spage>39</spage><epage>42</epage><pages>39-42</pages><issn>0367-326X</issn><eissn>1873-6971</eissn><abstract>Bio-guided fractionation of the roots of
Paris polyphylla (Trilliaceae), based on inhibition of P-glycoprotein-mediated daunorubicin efflux in K562/R7 cell line, led to isolation and identification of the three saponins 3-
O-Rha(1
→
2)[Ara(1
→
4)]Glc-pennogenine, gracillin and polyphyllin D, and the two ecdysteroids 20-hydroxyecdysone and pinnatasterone. These compounds were tested for multidrug reversion on P-glycoprotein (ABCB1) with both drug-selected and transfected cell lines, and also on Breast Cancer Resistance Protein (BCRP/ABCG2). By contrast to a weak efficiency on BCRP, the three saponins displayed significant effects as inhibitors of P-glycoprotein-mediated drug efflux.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18940238</pmid><doi>10.1016/j.fitote.2008.09.010</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-8035-214X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0367-326X |
| ispartof | Fitoterapia, 2009, Vol.80 (1), p.39-42 |
| issn | 0367-326X 1873-6971 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02545047v1 |
| source | Elsevier |
| subjects | ABCB1 Analytical chemistry BCRP (ABCG2) Biological and medical sciences Breast Cancer Resistance Protein Chemical Sciences Ecdysteroids General pharmacology Life Sciences MDR Medical sciences Multidrug resistance P-glycoprotein Paris polyphylla Pharmaceutical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Saponins |
| title | Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla |
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