Cytotoxic and Antiplasmodial Xanthones from Pentadesma butyracea

Four new xanthones, butyraxanthones A−D (1−4), were isolated from the stem bark of Pentadesma butyracea, together with six known xanthones (5−10) and a triterpenoid (lupeol). The structures of 1−4 were established by spectroscopic methods. Compounds 1−10 were tested in vitro for antiplasmodial activ...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2009-05, Vol.72 (5), p.954-957
Main Authors: Zelefack, Fabien, Guilet, David, Fabre, Nicolas, Bayet, Christine, Chevalley, Séverine, Ngouela, Silvère, Lenta, Bruno Ndjakou, Valentin, Alexis, Tsamo, Etienne, Dijoux-Franca, Marie-Geneviève
Format: Article
Language:English
Subjects:
anticarcinogenic activity
antimalarial activity
antimalarials
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
antiplasmodial activity
bark
Biological and medical sciences
butyraxanthones
Cameroon
cancer cell lines
chemical structure
Chloroquine - pharmacology
Clusiaceae
Clusiaceae - chemistry
cytotoxicity
Drug Screening Assays, Antitumor
Female
General pharmacology
human cell lines
Humans
isolation
Life Sciences
Medical sciences
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Parasitic Sensitivity Tests
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Bark - chemistry
plant extracts
Plant Stems - chemistry
Plants, Medicinal - chemistry
Plasmodium falciparum
Plasmodium falciparum - drug effects
xanthones
Xanthones - chemistry
Xanthones - isolation & purification
Xanthones - pharmacology
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Summary:Four new xanthones, butyraxanthones A−D (1−4), were isolated from the stem bark of Pentadesma butyracea, together with six known xanthones (5−10) and a triterpenoid (lupeol). The structures of 1−4 were established by spectroscopic methods. Compounds 1−10 were tested in vitro for antiplasmodial activity against a Plasmodium falciparum chloroquine-resistant strain and for cytotoxicity against a human breast cancer cell line (MCF-7). Nearly all of these xanthones exhibited good antiplasmodial activity, and some of them also demonstrated potent cytotoxicity.
ISSN:0163-3864
1520-6025
DOI:10.1021/np8005953