Metal-Organic Frameworks as Efficient Materials for Drug Delivery

Fill 'em up: The metal carboxylates MIL‐100 and MIL‐101 act as porous matrices (see picture; MIL=Materials of Institut Lavoisier) for drug‐delivery systems using Ibuprofen as a model substrate. Very large amounts of the drug could be incorporated, up to an unprecedented capacity of 1.4 g of dru...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2006-09, Vol.45 (36), p.5974-5978
Main Authors: Horcajada, Patricia, Serre, Christian, Vallet-Regí, María, Sebban, Muriel, Taulelle, Francis, Férey, Gérard
Format: Article
Language:English
Subjects:
Analytical chemistry
Biocompatible Materials - chemistry
Body Fluids - chemistry
Chemical Sciences
Computer Simulation
controlled delivery
drug delivery
Drug Delivery Systems
Humans
hybrid materials
Ibuprofen - chemistry
Inorganic chemistry
Magnetic Resonance Spectroscopy
Metals - chemistry
Organometallic Compounds - chemistry
porous materials
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Summary:Fill 'em up: The metal carboxylates MIL‐100 and MIL‐101 act as porous matrices (see picture; MIL=Materials of Institut Lavoisier) for drug‐delivery systems using Ibuprofen as a model substrate. Very large amounts of the drug could be incorporated, up to an unprecedented capacity of 1.4 g of drug per gram of porous solid for MIL‐101, and the total release of Ibuprofen was achieved under physiological conditions in 3 (MIL‐100) and 6 days (MIL‐101).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200601878