Multiple sclerosis broke my heart

We report 5 cases of acute heart failure (AHF) related to multiple sclerosis (MS) relapses. AHF was inaugural in 3 patients, always preceded or accompanied by signs of brainstem dysfunction; it was severe, requiring intensive care management. Echocardiography showed left ventricular hypokinesis. No...

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Bibliographic Details
Published in:Annals of neurology 2017-05, Vol.81 (5), p.754-758
Main Authors: Androdias, Géraldine, Bernard, Emilien, Biotti, Damien, Collongues, Nicolas, Durand‐Dubief, Françoise, Pique, Julie, Sanchez, Ingrid, Delmas, Clément, Ninet, Jacques, Marignier, Romain, Vukusic, Sandra
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brain
Brain stem
Cardiomyopathy
Corticoids
Corticosteroids
Echocardiography
Female
Heart
Heart diseases
Heart Failure - diagnostic imaging
Heart Failure - drug therapy
Heart Failure - etiology
Humans
Intravenous administration
Life Sciences
Magnetic Resonance Imaging
Male
Medical personnel
Medulla Oblongata - diagnostic imaging
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - complications
Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging
Multiple Sclerosis, Relapsing-Remitting - physiopathology
Neuroimaging
Neurons and Cognition
Patients
Physicians
Takotsubo Cardiomyopathy - diagnostic imaging
Takotsubo Cardiomyopathy - drug therapy
Takotsubo Cardiomyopathy - etiology
Ventricle
Young Adult
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Summary:We report 5 cases of acute heart failure (AHF) related to multiple sclerosis (MS) relapses. AHF was inaugural in 3 patients, always preceded or accompanied by signs of brainstem dysfunction; it was severe, requiring intensive care management. Echocardiography showed left ventricular hypokinesis. No other cause of AHF has been found. All patients showed a new medullary lesion on brain magnetic resonance imaging. All had rapid and complete recovery of ventricular function after intravenous corticosteroids. We concluded that the cases represent a takotsubo phenomenon. Physicians should be aware of rare cases of takotsubo cardiomyopathy in MS relapses. Ann Neurol 2017;81:754–758
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.24935