In vivo biodistribution of platinum-based drugs encapsulated into multi-walled carbon nanotubes

Abstract Carbon nanotubes (CNTs) are promising drug delivery systems due to their external functionalizable surface and their hollowed cavity that can encapsulate several bioactive molecules. In this study, the chemotherapeutic drug cisplatin or an inert platinum(IV) complex were entrapped inside fu...

Full description

Saved in:
Bibliographic Details
Published in:Nanomedicine 2014-10, Vol.10 (7), p.1465-1475
Main Authors: Li, Jian, PhD, Pant, Aakansha, Chin, Chee Fei, Ang, Wee Han, PhD, Ménard-Moyon, Cécilia, PhD, Nayak, Tapas R., PhD, Gibson, Dan, PhD, Ramaprabhu, Sundara, PhD, Panczyk, Tomasz, PhD, Bianco, Alberto, PhD, Pastorin, Giorgia, PhD
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacokinetics
Biodistribution
Carbon nanotubes
Chemical Sciences
Drug Carriers
Drug delivery
Female
Histopathology
Internal Medicine
Medicinal Chemistry
Mice
Mice, Inbred BALB C
Nanotubes, Carbon
Platinum Compounds - pharmacokinetics
Platinum-based drugs
Tissue Distribution
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Carbon nanotubes (CNTs) are promising drug delivery systems due to their external functionalizable surface and their hollowed cavity that can encapsulate several bioactive molecules. In this study, the chemotherapeutic drug cisplatin or an inert platinum(IV) complex were entrapped inside functionalized-multi-walled-CNTs and intravenously injected into mice to investigate the influence of CNTs on the biodistribution of Pt-based molecules. The platinum levels in vital organs suggested that functionalized-CNTs did not affect cisplatin distribution, while they significantly enhanced the accumulation of Pt(IV) sample in some tissues (e.g. in the lungs, suggesting their potential application in lung cancer therapy) and reduced both kidney and liver accumulation (thus decreasing eventual nephrotoxicity, a typical side effect of cisplatin). Concurrently, CNTs did not induce any intrinsic abnormal immune response or inflammation, as confirmed by normal cytokine levels and histological evaluations. Therefore, functionalized nanotubes represent an efficient nano-carrier to improve accumulation of Pt species in targeted tissues/organs. From the Clinical Editor In this preclinical study functionalized carbon nanotubes are reported to be safe and efficient for targeted delivery of platinum-containing compounds in rodents. Approaches like this may improve the treatment of specific cancers, since platinum based chemotherapies are commonly used, yet limited by toxicity and relatively poor target tissue concentration.
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2014.01.004