Multidrug-resistant Plasmodium falciparum malaria in the Greater Mekong subregion

[...]the authors observed a single major origin of plasmepsin 2-3 amplifications, indicating that piperaquine-resistant P falciparum parasites were probably derived from the same epidemiological origin (named the PLA1 lineage by the authors). [...]they showed that dihydroartemisinin-piperaquine resi...

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Bibliographic Details
Published in:The Lancet infectious diseases 2018-03, Vol.18 (3), p.238-239
Main Authors: Ménard, Didier, Clain, Jérôme, Ariey, Frédéric
Format: Article
Language:English
Subjects:
Anopheles
Aquatic insects
Asia, Southeastern
Culicidae
Dihydroartemisinin
Disease Outbreaks
Drug resistance
Emerging diseases
Epidemiology
Erythrocytes
Gametocytes
Human health and pathology
Humans
Infectious diseases
Life Sciences
Malaria
Malaria - epidemiology
Malaria, Falciparum
Malaria, Falciparum - epidemiology
Microbiology and Parasitology
Multidrug resistance
Mutation
Parasites
Parasitology
Plasmodium falciparum
Population
Retrospective Studies
Vector-borne diseases
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Summary:[...]the authors observed a single major origin of plasmepsin 2-3 amplifications, indicating that piperaquine-resistant P falciparum parasites were probably derived from the same epidemiological origin (named the PLA1 lineage by the authors). [...]they showed that dihydroartemisinin-piperaquine resistance rapidly spread via diffusion of the KEL1/PLA1 co-lineage from western to northeastern Cambodia. [...]the early events associated with dihydroartemisinin-piperaquine resistance should be identified through analysis of samples collected before 2007. [...]studies could investigate additional mutations, genetic determinants, and specific genetic backgrounds conferring selective advantage to the KEL1/PLA1 co-lineage (eg, increased drug resistance, improved fitness of the asexual stages in the human host, increased transmissibility by increasing gametocyte numbers, favouring transmission to Anopheles spp mosquitoes).
ISSN:1473-3099
1474-4457
1474-4457
DOI:10.1016/S1473-3099(18)30071-9