Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25 years of research in chemistry and biology

Since the beginning of the 1990's diverse types of metabolites originating from polyunsaturated fatty acids, formed under autooxidative conditions were discovered. Known as prostaglandin isomers (or isoprostanoids) originating from arachidonic acid, neuroprostanes from docosahexaenoic acid, and...

Full description

Saved in:
Bibliographic Details
Published in:Progress in lipid research 2017-10, Vol.68, p.83-108
Main Authors: Galano, Jean-Marie, Lee, Yiu Yiu, Oger, Camille, Vigor, Claire, Vercauteren, Joseph, Durand, Thierry, Giera, Martin, Lee, Jetty Chung-Yung
Format: Article
Language:English
Subjects:
Analytical chemistry
Biochemistry
Biochemistry, Molecular Biology
Chemical Sciences
Human health and pathology
Life Sciences
Organic chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Since the beginning of the 1990's diverse types of metabolites originating from polyunsaturated fatty acids, formed under autooxidative conditions were discovered. Known as prostaglandin isomers (or isoprostanoids) originating from arachidonic acid, neuroprostanes from docosahexaenoic acid, and phytoprostanes from α-li-nolenic acid proved to be prevalent in biology. The syntheses of these compounds by organic chemists and the development of sophisticated mass spectrometry methods has boosted our understanding of the isoprostanoid biology. In recent years, it has become accepted that these molecules not only serve as markers of oxidative damage but also exhibit a wide range of bioactivities. In addition, isoprostanoids have emerged as indicators of oxidative stress in humans and their environment. This review explores in detail the isoprostanoid chemistry and biology that has been achieved in the past three decades.
ISSN:0163-7827
DOI:10.1016/j.plipres.2017.09.004