Prenatal natural history of congenital pulmonary malformations: MALFPULM population‐based cohort study

• Published in: Ultrasound in obstetrics & gynecology 2019-09, Vol.54 (3), p.381-388
• Main Authors: Delacourt, C., Bertille, N., Salomon, L. J., Benachi, A., Henry, E., Massardier, J., Mottet, N., Rosenblatt, J., Sartor, A., Thong‐Vanh, C., Valat‐Rigot, A. S., Winer, N., Lelong, N., Khoshnood, B., Alanio, E., Bory, J.‐P., Aquilue, L. N., Choupeaux, L., Hauw, C., Banaszkiewicz, N., Bertorello, S., Lebouar, G., Biquard, F., Sentilhes, L., Bonfiglioli, V., Carbillon, L., Bonnard, A., Bremont, F., Bultez, T., Roth, P., Stirnemann, J., Ville, Y., Castaigne, V., Touboul, C., Coatleven, F., Mangione, R., Darras, A.‐M., Guilbaud, L., Jouannic, J.‐M., Dazel‐Salonne, C., Ducoin, H., Dugue‐Marechaud, M., Goua, V., Eszto‐Cambon, M.‐L., Fange, C., Prieur, F., Favre, R., Feghali, H., Goffinet, F., Tsatsaris, V., Gondry, J., Muszynski, C., Hameury, F., Laurichesse, H., Lebras, M.‐N., Letourneau, A., Saada, J., Morel, O., Perdriolle, E., Morin, M., Mousty, E., Oury, J.‐F., Paris, A., Perrotin, F., Piolat, C., Podevin, G., Quibel, T., Rakza, T., Saliou, A.‐H., Sfeir, R., Thumerelle, C., Trastour, C.
• Format: Article
• Language: English
• Subjects: Adult; Age; CCAM; Cohort analysis; Compression; congenital cystic adenomatoid malformation; Congenital defects; congenital pulmonary malformation volume ratio; CVR; Cystic Adenomatoid Malformation of Lung, Congenital - diagnosis; Diagnosis; Diagnostic systems; Female; Fetal Diseases - diagnosis; Fetuses; Gestation; Gestational Age; Health risk assessment; Human health and pathology; Humans; hydrops; Lesions; Life Sciences; lung development; Phenotypes; Population studies; Population-based studies; Pregnancy; Prenatal Care; Prognosis; Prospective Studies; Santé publique et épidémiologie; sequestration; Statistical analysis; Ultrasonic imaging; Ultrasonography, Prenatal; Ultrasound
• ISSN: 0960-7692; 1469-0705
• DOI: 10.1002/uog.20130

ABSTRACT Objectives To assess prenatal changes in the volume of congenital pulmonary malformations (CPM) and examine whether these changes differ in lesions that appear cystic on ultrasound compared with hyperechoic lesions, and to study the relationship between CPM volume and risk of fetal compression. Methods We conducted a nationally representative, multicenter, prospective cohort study, which included 579 ultrasound examinations in 176 pregnant women with a diagnosis of fetal CPM, between March 2015 and November 2016. Several ultrasound examinations were performed between diagnosis and delivery, including measurement of CPM volume. We modeled changes in CPM volume ratio (CVR) as a function of gestational age, overall and for cystic/mixed vs hyperechoic malformations, and examined the association between CVR and signs of compression during pregnancy. Results When modeling CVR changes over time, there was a statistically significant decrease in CVR with increasing gestational age (P