Age-specific changes in left ventricular diastolic function: A velocity-encoded magnetic resonance imaging study

Objectives Our objectives were to assess the ability of phasecontrast MRI (PC-MRI) to detect sub-clinical age-related variations of left ventricular (LV) diastolic parameters and thus to provide age-related reference ranges currently available for echocardiography but not for MRI-PC, and to identify...

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Bibliographic Details
Published in:European radiology 2015-04, Vol.25 (4), p.1077-1086
Main Authors: Ashrafpoor, Golmehr, Bollache, Emilie, Redheuil, Alban, De Cesare, Alain, Giron, Alain, Defrance, Carine, Azarine, Arshid, Perdrix, Ludivine, Ladouceur, Magalie, Diebold, Benoît, Mousseaux, Elie, Kachenoura, Nadjia
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aging
Aging - physiology
Asymptomatic
Blood pressure
Body mass index
Diagnostic Radiology
Diastole
Doppler effect
Ejection fraction
Female
Healthy Volunteers
Heart failure
Heart Ventricles - anatomy & histology
Human health and pathology
Humans
Imaging
Internal Medicine
Interventional Radiology
Life Sciences
Magnetic Resonance
Magnetic resonance imaging
Magnetic Resonance Imaging, Cine - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Physiology
Radiology
Ultrasound
Velocity
Ventricular Function, Left - physiology
Young Adult
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Summary:Objectives Our objectives were to assess the ability of phasecontrast MRI (PC-MRI) to detect sub-clinical age-related variations of left ventricular (LV) diastolic parameters and thus to provide age-related reference ranges currently available for echocardiography but not for MRI-PC, and to identify independent associates of such variations. Methods We studied 100 healthy volunteers (age = 42 ± 15years, 50 females) who had MRI with simultaneous blood pressure measurements. LV mass and volumes were assessed. Semiautomated analysis of PC-MRI data provided: 1) early transmitral (Ef) and atrial (Af) peak filling flow-rates (ml/s) and filling volume (FV), 2) deceleration time (DT), isovolumic relaxation time (IVRT), and 3) early myocardial longitudinal (E’) peak velocity. Results MRI-PC diastolic parameters were reproducible as reflected by low coefficients of variations (ranged between 0.31 to 6.26 %). Peak myocardial velocity E’ ( r  = −0.63, p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-014-3488-z