Palladium and copper catalyzed Sonogashira decarboxylative coupling of aryl iodides and alkynyl carboxylic acids

[Display omitted] •The use of microwave conditions that optimize the reaction time.•Transferring small alkyne patterns on aryl bromide and iodide.•A methodology using conventional reagents and easy to implement. A mild procedure of palladium and copper catalyzed decarboxylative cross-coupling reacti...

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Bibliographic Details
Published in:Tetrahedron letters 2016-07, Vol.57 (30), p.3358-3362
Main Authors: Maaliki, Carine, Chevalier, Yoan, Thiery, Emilie, Thibonnet, Jérôme
Format: Article
Language:English
Subjects:
Alkynyl carboxylic acids
Aryl halides
Chemical Sciences
Copper
Decarboxylative coupling
Organic chemistry
Palladium
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Summary:[Display omitted] •The use of microwave conditions that optimize the reaction time.•Transferring small alkyne patterns on aryl bromide and iodide.•A methodology using conventional reagents and easy to implement. A mild procedure of palladium and copper catalyzed decarboxylative cross-coupling reaction of aryl halides and alkynyl carboxylic acids has been developed. Low molecular weight acids, to introduce small building blocks, were specifically used. This methodology is easy to implement and uses common reactants and catalysts.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2016.06.073