Prion and prion-like diseases in animals

•In this review, we provide a description of the prion and prion-like diseases affecting animals.•We review the ability of certain non-prion proteins to misfold and self-propagate.•We review the recent findings suggesting the transmissibility of some prion-like diseases affecting animals. Transmissi...

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Bibliographic Details
Published in:Virus research 2015-09, Vol.207, p.82-93
Main Authors: Aguilar-Calvo, Patricia, García, Consolación, Espinosa, Juan Carlos, Andreoletti, Olivier, Torres, Juan María
Format: Article
Language:English
Subjects:
Amyloid
Amyloidosis
Animals
Cats
Cattle
Life Sciences
Mink
Prion
Prion Diseases - metabolism
Prion Diseases - transmission
Prion Diseases - veterinary
Prion-like transmission
Prions - genetics
Prions - metabolism
Protein misfolding
Protein self-templating
Sheep
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Summary:•In this review, we provide a description of the prion and prion-like diseases affecting animals.•We review the ability of certain non-prion proteins to misfold and self-propagate.•We review the recent findings suggesting the transmissibility of some prion-like diseases affecting animals. Transmissible spongiform encephalopaties (TSEs) are fatal neurodegenerative diseases characterized by the aggregation and accumulation of the misfolded prion protein in the brain. Other proteins such as β-amyloid, tau or Serum Amyloid-A (SAA) seem to share with prions some aspects of their pathogenic mechanism; causing a variety of so called prion-like diseases in humans and/or animals such as Alzheimer's, Parkinson's, Huntington's, Type II diabetes mellitus or amyloidosis. The question remains whether these misfolding proteins have the ability to self-propagate and transmit in a similar manner to prions. In this review, we describe the prion and prion-like diseases affecting animals as well as the recent findings suggesting the prion-like transmissibility of certain non-prion proteins.
ISSN:0168-1702
1872-7492
DOI:10.1016/j.virusres.2014.11.026